The Controversial Role of Polyploidy in Hepatocellular Carcinoma

Nan Wang,1,&ast; Fengjie Hao,1,&ast; Yan Shi,2 Junqing Wang1 1Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 2Department of Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Sh...

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Autores principales:	Wang N, Hao F, Shi Y, Wang J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	polyploidy liver hepatocyte cancer cell cycle. Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/84ec80b1f4344e158d3a2295e1af8e8d
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spelling	oai:doaj.org-article:84ec80b1f4344e158d3a2295e1af8e8d2021-11-28T19:13:10ZThe Controversial Role of Polyploidy in Hepatocellular Carcinoma1178-6930https://doaj.org/article/84ec80b1f4344e158d3a2295e1af8e8d2021-11-01T00:00:00Zhttps://www.dovepress.com/the-controversial-role-of-polyploidy-in-hepatocellular-carcinoma-peer-reviewed-fulltext-article-OTThttps://doaj.org/toc/1178-6930Nan Wang,1,&ast; Fengjie Hao,1,&ast; Yan Shi,2 Junqing Wang1 1Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 2Department of Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yan Shi; Junqing Wang Email sy_rjh@aliyun.com; wangjunqingmd@hotmail.comAbstract: Polyploidy, a physiological phenomenon in which cells contain more than two sets of homologous chromosomes, commonly exists in plants, fish, and amphibians but is rare in mammals. In humans, polyploid cells are detected commonly in specific organs or tissues including the heart, marrow, and liver. As the largest solid organ in the body, the liver is responsible for a myriad of functions, most of which are closely related to polyploid hepatocytes. It has been confirmed that polyploid hepatocytes are related to liver regeneration, homeostasis, terminal differentiation, and aging. Polyploid hepatocytes accumulate during the aging process as well as in chronically injured livers. The relationship between polyploid hepatocytes and hepatocellular carcinoma, the endpoint of most chronic liver diseases, is not yet fully understood. Recently, accumulated evidence has revealed that polyploid involves in the process of tumorigenesis and development. The study of the correlation and relationship between polyploidy hepatocytes and the development of hepatocellular carcinoma can potentially promote the prevention, early diagnosis, and treatment of hepatocellular carcinoma. In this review, we conclude the potential mechanisms of polyploid hepatocytes formation, focusing on the specific biological significance of polyploid hepatocytes. In addition, we examine recent discoveries that have begun to clarify the relevance between polyploid hepatocytes and hepatocellular carcinoma and discuss recent excellent findings that reveal the role of polyploid hepatocytes as resisters of hepatocellular carcinoma or as promoters of hepatocarcinogenesis.Keywords: polyploidy, liver, hepatocyte, cancer, cell cycleWang NHao FShi YWang JDove Medical Pressarticlepolyploidyliverhepatocytecancercell cycle.Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENOncoTargets and Therapy, Vol Volume 14, Pp 5335-5344 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	polyploidy liver hepatocyte cancer cell cycle. Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	polyploidy liver hepatocyte cancer cell cycle. Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Wang N Hao F Shi Y Wang J The Controversial Role of Polyploidy in Hepatocellular Carcinoma
description	Nan Wang,1,&ast; Fengjie Hao,1,&ast; Yan Shi,2 Junqing Wang1 1Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 2Department of Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yan Shi; Junqing Wang Email sy_rjh@aliyun.com; wangjunqingmd@hotmail.comAbstract: Polyploidy, a physiological phenomenon in which cells contain more than two sets of homologous chromosomes, commonly exists in plants, fish, and amphibians but is rare in mammals. In humans, polyploid cells are detected commonly in specific organs or tissues including the heart, marrow, and liver. As the largest solid organ in the body, the liver is responsible for a myriad of functions, most of which are closely related to polyploid hepatocytes. It has been confirmed that polyploid hepatocytes are related to liver regeneration, homeostasis, terminal differentiation, and aging. Polyploid hepatocytes accumulate during the aging process as well as in chronically injured livers. The relationship between polyploid hepatocytes and hepatocellular carcinoma, the endpoint of most chronic liver diseases, is not yet fully understood. Recently, accumulated evidence has revealed that polyploid involves in the process of tumorigenesis and development. The study of the correlation and relationship between polyploidy hepatocytes and the development of hepatocellular carcinoma can potentially promote the prevention, early diagnosis, and treatment of hepatocellular carcinoma. In this review, we conclude the potential mechanisms of polyploid hepatocytes formation, focusing on the specific biological significance of polyploid hepatocytes. In addition, we examine recent discoveries that have begun to clarify the relevance between polyploid hepatocytes and hepatocellular carcinoma and discuss recent excellent findings that reveal the role of polyploid hepatocytes as resisters of hepatocellular carcinoma or as promoters of hepatocarcinogenesis.Keywords: polyploidy, liver, hepatocyte, cancer, cell cycle
format	article
author	Wang N Hao F Shi Y Wang J
author_facet	Wang N Hao F Shi Y Wang J
author_sort	Wang N
title	The Controversial Role of Polyploidy in Hepatocellular Carcinoma
title_short	The Controversial Role of Polyploidy in Hepatocellular Carcinoma
title_full	The Controversial Role of Polyploidy in Hepatocellular Carcinoma
title_fullStr	The Controversial Role of Polyploidy in Hepatocellular Carcinoma
title_full_unstemmed	The Controversial Role of Polyploidy in Hepatocellular Carcinoma
title_sort	controversial role of polyploidy in hepatocellular carcinoma
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/84ec80b1f4344e158d3a2295e1af8e8d
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The Controversial Role of Polyploidy in Hepatocellular Carcinoma

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