Similarity in viral and host promoters couples viral reactivation with host cell migration

The coevolution of viruses and host cells can be mapped with interactomics. Here the authors identify coupling of human and viral promoters, and show that HIV-reactivation from dormancy is coincident with migration of HIV-infected cells owing to coupling of human CXCR4 and HIV LTR promoters.

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Autores principales: Kathrin Bohn-Wippert, Erin N. Tevonian, Melina R. Megaridis, Roy D. Dar
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Q
Acceso en línea:https://doaj.org/article/84fb8ac5c6054278bd414c55e84ad044
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