Similarity in viral and host promoters couples viral reactivation with host cell migration
The coevolution of viruses and host cells can be mapped with interactomics. Here the authors identify coupling of human and viral promoters, and show that HIV-reactivation from dormancy is coincident with migration of HIV-infected cells owing to coupling of human CXCR4 and HIV LTR promoters.
Guardado en:
Autores principales: | , , , |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
|
Materias: | |
Acceso en línea: | https://doaj.org/article/84fb8ac5c6054278bd414c55e84ad044 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:84fb8ac5c6054278bd414c55e84ad044 |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:84fb8ac5c6054278bd414c55e84ad0442021-12-02T17:06:06ZSimilarity in viral and host promoters couples viral reactivation with host cell migration10.1038/ncomms150062041-1723https://doaj.org/article/84fb8ac5c6054278bd414c55e84ad0442017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15006https://doaj.org/toc/2041-1723The coevolution of viruses and host cells can be mapped with interactomics. Here the authors identify coupling of human and viral promoters, and show that HIV-reactivation from dormancy is coincident with migration of HIV-infected cells owing to coupling of human CXCR4 and HIV LTR promoters.Kathrin Bohn-WippertErin N. TevonianMelina R. MegaridisRoy D. DarNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
Science Q |
spellingShingle |
Science Q Kathrin Bohn-Wippert Erin N. Tevonian Melina R. Megaridis Roy D. Dar Similarity in viral and host promoters couples viral reactivation with host cell migration |
description |
The coevolution of viruses and host cells can be mapped with interactomics. Here the authors identify coupling of human and viral promoters, and show that HIV-reactivation from dormancy is coincident with migration of HIV-infected cells owing to coupling of human CXCR4 and HIV LTR promoters. |
format |
article |
author |
Kathrin Bohn-Wippert Erin N. Tevonian Melina R. Megaridis Roy D. Dar |
author_facet |
Kathrin Bohn-Wippert Erin N. Tevonian Melina R. Megaridis Roy D. Dar |
author_sort |
Kathrin Bohn-Wippert |
title |
Similarity in viral and host promoters couples viral reactivation with host cell migration |
title_short |
Similarity in viral and host promoters couples viral reactivation with host cell migration |
title_full |
Similarity in viral and host promoters couples viral reactivation with host cell migration |
title_fullStr |
Similarity in viral and host promoters couples viral reactivation with host cell migration |
title_full_unstemmed |
Similarity in viral and host promoters couples viral reactivation with host cell migration |
title_sort |
similarity in viral and host promoters couples viral reactivation with host cell migration |
publisher |
Nature Portfolio |
publishDate |
2017 |
url |
https://doaj.org/article/84fb8ac5c6054278bd414c55e84ad044 |
work_keys_str_mv |
AT kathrinbohnwippert similarityinviralandhostpromoterscouplesviralreactivationwithhostcellmigration AT erinntevonian similarityinviralandhostpromoterscouplesviralreactivationwithhostcellmigration AT melinarmegaridis similarityinviralandhostpromoterscouplesviralreactivationwithhostcellmigration AT royddar similarityinviralandhostpromoterscouplesviralreactivationwithhostcellmigration |
_version_ |
1718381740142100480 |