Similarity in viral and host promoters couples viral reactivation with host cell migration

The coevolution of viruses and host cells can be mapped with interactomics. Here the authors identify coupling of human and viral promoters, and show that HIV-reactivation from dormancy is coincident with migration of HIV-infected cells owing to coupling of human CXCR4 and HIV LTR promoters.

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Autores principales: Kathrin Bohn-Wippert, Erin N. Tevonian, Melina R. Megaridis, Roy D. Dar
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/84fb8ac5c6054278bd414c55e84ad044
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spelling oai:doaj.org-article:84fb8ac5c6054278bd414c55e84ad0442021-12-02T17:06:06ZSimilarity in viral and host promoters couples viral reactivation with host cell migration10.1038/ncomms150062041-1723https://doaj.org/article/84fb8ac5c6054278bd414c55e84ad0442017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15006https://doaj.org/toc/2041-1723The coevolution of viruses and host cells can be mapped with interactomics. Here the authors identify coupling of human and viral promoters, and show that HIV-reactivation from dormancy is coincident with migration of HIV-infected cells owing to coupling of human CXCR4 and HIV LTR promoters.Kathrin Bohn-WippertErin N. TevonianMelina R. MegaridisRoy D. DarNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Kathrin Bohn-Wippert
Erin N. Tevonian
Melina R. Megaridis
Roy D. Dar
Similarity in viral and host promoters couples viral reactivation with host cell migration
description The coevolution of viruses and host cells can be mapped with interactomics. Here the authors identify coupling of human and viral promoters, and show that HIV-reactivation from dormancy is coincident with migration of HIV-infected cells owing to coupling of human CXCR4 and HIV LTR promoters.
format article
author Kathrin Bohn-Wippert
Erin N. Tevonian
Melina R. Megaridis
Roy D. Dar
author_facet Kathrin Bohn-Wippert
Erin N. Tevonian
Melina R. Megaridis
Roy D. Dar
author_sort Kathrin Bohn-Wippert
title Similarity in viral and host promoters couples viral reactivation with host cell migration
title_short Similarity in viral and host promoters couples viral reactivation with host cell migration
title_full Similarity in viral and host promoters couples viral reactivation with host cell migration
title_fullStr Similarity in viral and host promoters couples viral reactivation with host cell migration
title_full_unstemmed Similarity in viral and host promoters couples viral reactivation with host cell migration
title_sort similarity in viral and host promoters couples viral reactivation with host cell migration
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/84fb8ac5c6054278bd414c55e84ad044
work_keys_str_mv AT kathrinbohnwippert similarityinviralandhostpromoterscouplesviralreactivationwithhostcellmigration
AT erinntevonian similarityinviralandhostpromoterscouplesviralreactivationwithhostcellmigration
AT melinarmegaridis similarityinviralandhostpromoterscouplesviralreactivationwithhostcellmigration
AT royddar similarityinviralandhostpromoterscouplesviralreactivationwithhostcellmigration
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