Similarity in viral and host promoters couples viral reactivation with host cell migration

The coevolution of viruses and host cells can be mapped with interactomics. Here the authors identify coupling of human and viral promoters, and show that HIV-reactivation from dormancy is coincident with migration of HIV-infected cells owing to coupling of human CXCR4 and HIV LTR promoters.

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Autores principales:	Kathrin Bohn-Wippert, Erin N. Tevonian, Melina R. Megaridis, Roy D. Dar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/84fb8ac5c6054278bd414c55e84ad044
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spelling	oai:doaj.org-article:84fb8ac5c6054278bd414c55e84ad0442021-12-02T17:06:06ZSimilarity in viral and host promoters couples viral reactivation with host cell migration10.1038/ncomms150062041-1723https://doaj.org/article/84fb8ac5c6054278bd414c55e84ad0442017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15006https://doaj.org/toc/2041-1723The coevolution of viruses and host cells can be mapped with interactomics. Here the authors identify coupling of human and viral promoters, and show that HIV-reactivation from dormancy is coincident with migration of HIV-infected cells owing to coupling of human CXCR4 and HIV LTR promoters.Kathrin Bohn-WippertErin N. TevonianMelina R. MegaridisRoy D. DarNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kathrin Bohn-Wippert Erin N. Tevonian Melina R. Megaridis Roy D. Dar Similarity in viral and host promoters couples viral reactivation with host cell migration
description	The coevolution of viruses and host cells can be mapped with interactomics. Here the authors identify coupling of human and viral promoters, and show that HIV-reactivation from dormancy is coincident with migration of HIV-infected cells owing to coupling of human CXCR4 and HIV LTR promoters.
format	article
author	Kathrin Bohn-Wippert Erin N. Tevonian Melina R. Megaridis Roy D. Dar
author_facet	Kathrin Bohn-Wippert Erin N. Tevonian Melina R. Megaridis Roy D. Dar
author_sort	Kathrin Bohn-Wippert
title	Similarity in viral and host promoters couples viral reactivation with host cell migration
title_short	Similarity in viral and host promoters couples viral reactivation with host cell migration
title_full	Similarity in viral and host promoters couples viral reactivation with host cell migration
title_fullStr	Similarity in viral and host promoters couples viral reactivation with host cell migration
title_full_unstemmed	Similarity in viral and host promoters couples viral reactivation with host cell migration
title_sort	similarity in viral and host promoters couples viral reactivation with host cell migration
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/84fb8ac5c6054278bd414c55e84ad044
work_keys_str_mv	AT kathrinbohnwippert similarityinviralandhostpromoterscouplesviralreactivationwithhostcellmigration AT erinntevonian similarityinviralandhostpromoterscouplesviralreactivationwithhostcellmigration AT melinarmegaridis similarityinviralandhostpromoterscouplesviralreactivationwithhostcellmigration AT royddar similarityinviralandhostpromoterscouplesviralreactivationwithhostcellmigration
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Similarity in viral and host promoters couples viral reactivation with host cell migration

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