Role of Granulocyte-Macrophage Colony-Stimulating Factor Production by T Cells during <italic toggle="yes">Mycobacterium tuberculosis</italic> Infection

Role of Granulocyte-Macrophage Colony-Stimulating Factor Production by T Cells during <italic toggle="yes">Mycobacterium tuberculosis</italic> Infection

ABSTRACT Mice deficient for granulocyte-macrophage colony-stimulating factor (GM-CSF−/−) are highly susceptible to infection with Mycobacterium tuberculosis, and clinical data have shown that anti-GM-CSF neutralizing antibodies can lead to increased susceptibility to tuberculosis in otherwise health...

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Bibliographic Details
Main Authors: Alissa C. Rothchild, Britni Stowell, Girija Goyal, Cláudio Nunes-Alves, Qianting Yang, Kadamba Papavinasasundaram, Christopher M. Sassetti, Glenn Dranoff, Xinchun Chen, Jinhee Lee, Samuel M. Behar
Format: article
Language:EN
Published: American Society for Microbiology 2017
Subjects:
GM-CSF
Mycobacterium tuberculosis
T cells
cytokines
lung infection
macrophages
Microbiology
QR1-502
Online Access:https://doaj.org/article/84fda4d38ff444bc83d207a27981150e
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