Intergenerational inheritance of high fat diet-induced cardiac lipotoxicity in Drosophila

Animal studies have shown that the nutritional status of parents can predispose the offspring to obesity and obesity-related diseases. Here the authors show that cardiac dysfunction induced by a high-fat diet persists for two generations in Drosophila, and that targeted expression of ATGL/bmm in the...

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Autores principales:	Maria Clara Guida, Ryan Tyge Birse, Alessandra Dall’Agnese, Paula Coutinho Toto, Soda Balla Diop, Antonello Mai, Peter D. Adams, Pier Lorenzo Puri, Rolf Bodmer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/85001e90453a42569a76b07b4ec8c15a
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spelling	oai:doaj.org-article:85001e90453a42569a76b07b4ec8c15a2021-12-02T15:35:08ZIntergenerational inheritance of high fat diet-induced cardiac lipotoxicity in Drosophila10.1038/s41467-018-08128-32041-1723https://doaj.org/article/85001e90453a42569a76b07b4ec8c15a2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08128-3https://doaj.org/toc/2041-1723Animal studies have shown that the nutritional status of parents can predispose the offspring to obesity and obesity-related diseases. Here the authors show that cardiac dysfunction induced by a high-fat diet persists for two generations in Drosophila, and that targeted expression of ATGL/bmm in the offspring, as well as inhibition of H3K27 trimethylation, is cardioprotective.Maria Clara GuidaRyan Tyge BirseAlessandra Dall’AgnesePaula Coutinho TotoSoda Balla DiopAntonello MaiPeter D. AdamsPier Lorenzo PuriRolf BodmerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maria Clara Guida Ryan Tyge Birse Alessandra Dall’Agnese Paula Coutinho Toto Soda Balla Diop Antonello Mai Peter D. Adams Pier Lorenzo Puri Rolf Bodmer Intergenerational inheritance of high fat diet-induced cardiac lipotoxicity in Drosophila
description	Animal studies have shown that the nutritional status of parents can predispose the offspring to obesity and obesity-related diseases. Here the authors show that cardiac dysfunction induced by a high-fat diet persists for two generations in Drosophila, and that targeted expression of ATGL/bmm in the offspring, as well as inhibition of H3K27 trimethylation, is cardioprotective.
format	article
author	Maria Clara Guida Ryan Tyge Birse Alessandra Dall’Agnese Paula Coutinho Toto Soda Balla Diop Antonello Mai Peter D. Adams Pier Lorenzo Puri Rolf Bodmer
author_facet	Maria Clara Guida Ryan Tyge Birse Alessandra Dall’Agnese Paula Coutinho Toto Soda Balla Diop Antonello Mai Peter D. Adams Pier Lorenzo Puri Rolf Bodmer
author_sort	Maria Clara Guida
title	Intergenerational inheritance of high fat diet-induced cardiac lipotoxicity in Drosophila
title_short	Intergenerational inheritance of high fat diet-induced cardiac lipotoxicity in Drosophila
title_full	Intergenerational inheritance of high fat diet-induced cardiac lipotoxicity in Drosophila
title_fullStr	Intergenerational inheritance of high fat diet-induced cardiac lipotoxicity in Drosophila
title_full_unstemmed	Intergenerational inheritance of high fat diet-induced cardiac lipotoxicity in Drosophila
title_sort	intergenerational inheritance of high fat diet-induced cardiac lipotoxicity in drosophila
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/85001e90453a42569a76b07b4ec8c15a
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Intergenerational inheritance of high fat diet-induced cardiac lipotoxicity in Drosophila

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