Single-nucleus RNA-seq and FISH identify coordinated transcriptional activity in mammalian myofibers
Whether skeletal muscle fibre gene expression is coordinated as a whole in different nuclei in the fibre is unclear. Here, the authors use single nucleus RNAseq and ATACseq to show the transcriptome heterogeneity of muscle nuclei in the adult mouse fibre, with correlations between the two datasets.
Saved in:
Main Authors: | Matthieu Dos Santos, Stéphanie Backer, Benjamin Saintpierre, Brigitte Izac, Muriel Andrieu, Franck Letourneur, Frederic Relaix, Athanassia Sotiropoulos, Pascal Maire |
---|---|
Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2020
|
Subjects: | |
Online Access: | https://doaj.org/article/8503a3a7129146fea7a01f6be4dfc5d6 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Single-nucleus RNA-seq identifies transcriptional heterogeneity in multinucleated skeletal myofibers
by: Michael J. Petrany, et al.
Published: (2020) -
Automatic and unbiased segmentation and quantification of myofibers in skeletal muscle
by: Ariel Waisman, et al.
Published: (2021) -
Identification of the suprachiasmatic nucleus venous portal system in the mammalian brain
by: Yifan Yao, et al.
Published: (2021) -
Maintenance of type 2 glycolytic myofibers with age by Mib1-Actn3 axis
by: Ji-Yun Seo, et al.
Published: (2021) -
In vivo partial reprogramming of myofibers promotes muscle regeneration by remodeling the stem cell niche
by: Chao Wang, et al.
Published: (2021)