SecY-mediated quality control prevents the translocation of non-gated porins

Abstract OmpC and OmpF are among the most abundant outer membrane proteins in E. coli and serve as hydrophilic channels to mediate uptake of small molecules including antibiotics. Influx selectivity is controlled by the so-called constriction zone or eyelet of the channel. Mutations in the loop doma...

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Auteurs principaux: Sebastian Jung, Verian Bader, Ana Natriashvili, Hans-Georg Koch, Konstanze F. Winklhofer, Jörg Tatzelt
Format: article
Langue:EN
Publié: Nature Portfolio 2020
Sujets:
R
Q
Accès en ligne:https://doaj.org/article/85496819d379446e91f9fae7cfa50b28
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