SecY-mediated quality control prevents the translocation of non-gated porins

Abstract OmpC and OmpF are among the most abundant outer membrane proteins in E. coli and serve as hydrophilic channels to mediate uptake of small molecules including antibiotics. Influx selectivity is controlled by the so-called constriction zone or eyelet of the channel. Mutations in the loop doma...

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Autores principales: Sebastian Jung, Verian Bader, Ana Natriashvili, Hans-Georg Koch, Konstanze F. Winklhofer, Jörg Tatzelt
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/85496819d379446e91f9fae7cfa50b28
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