Cooperative functions of ZnT1, metallothionein and ZnT4 in the cytoplasm are required for full activation of TNAP in the early secretory pathway.

Cooperative functions of ZnT1, metallothionein and ZnT4 in the cytoplasm are required for full activation of TNAP in the early secretory pathway.

The activation process of secretory or membrane-bound zinc enzymes is thought to be a highly coordinated process involving zinc transport, trafficking, transfer and coordination. We have previously shown that secretory and membrane-bound zinc enzymes are activated in the early secretory pathway (ESP...

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Autores principales: Shigeyuki Fujimoto, Naoya Itsumura, Tokuji Tsuji, Yasumi Anan, Natsuko Tsuji, Yasumitsu Ogra, Tomoki Kimura, Yusaku Miyamae, Seiji Masuda, Masaya Nagao, Taiho Kambe
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/8569074a09b24ded9d485deda3637757
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