Overexpression of wild-type human amyloid precursor protein alters GABAergic transmission

Overexpression of wild-type human amyloid precursor protein alters GABAergic transmission

Abstract The function of the amyloid precursor protein (APP) is not fully understood, but its cleavage product amyloid beta (Aβ) together with neurofibrillary tangles constitute the hallmarks of Alzheimer’s disease (AD). Yet, imbalance of excitatory and inhibitory neurotransmission accompanied by lo...

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Main Authors: Anna Kreis, Jana Desloovere, Nuria Suelves, Nathalie Pierrot, Xavier Yerna, Farah Issa, Olivier Schakman, Roberta Gualdani, Marie de Clippele, Nicolas Tajeddine, Pascal Kienlen-Campard, Robrecht Raedt, Jean-Noël Octave, Philippe Gailly
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/8573bf1d0f514383a0caa67d43212752
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https://doaj.org/article/8573bf1d0f514383a0caa67d43212752

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