Fast and covariate-adaptive method amplifies detection power in large-scale multiple hypothesis testing

Side information in addition to the p-values is often available in modern applications of multiple hypothesis testing. Here, the authors develop AdaFDR, a new statistical method for multiple hypothesis testing that adaptively learns the decision threshold and amplifies the discovery power.

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Detalles Bibliográficos
Autores principales:	Martin J. Zhang, Fei Xia, James Zou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/857c63f9248a49b7a4152050747075ac
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spelling	oai:doaj.org-article:857c63f9248a49b7a4152050747075ac2021-12-02T17:01:52ZFast and covariate-adaptive method amplifies detection power in large-scale multiple hypothesis testing10.1038/s41467-019-11247-02041-1723https://doaj.org/article/857c63f9248a49b7a4152050747075ac2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11247-0https://doaj.org/toc/2041-1723Side information in addition to the p-values is often available in modern applications of multiple hypothesis testing. Here, the authors develop AdaFDR, a new statistical method for multiple hypothesis testing that adaptively learns the decision threshold and amplifies the discovery power.Martin J. ZhangFei XiaJames ZouNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Martin J. Zhang Fei Xia James Zou Fast and covariate-adaptive method amplifies detection power in large-scale multiple hypothesis testing
description	Side information in addition to the p-values is often available in modern applications of multiple hypothesis testing. Here, the authors develop AdaFDR, a new statistical method for multiple hypothesis testing that adaptively learns the decision threshold and amplifies the discovery power.
format	article
author	Martin J. Zhang Fei Xia James Zou
author_facet	Martin J. Zhang Fei Xia James Zou
author_sort	Martin J. Zhang
title	Fast and covariate-adaptive method amplifies detection power in large-scale multiple hypothesis testing
title_short	Fast and covariate-adaptive method amplifies detection power in large-scale multiple hypothesis testing
title_full	Fast and covariate-adaptive method amplifies detection power in large-scale multiple hypothesis testing
title_fullStr	Fast and covariate-adaptive method amplifies detection power in large-scale multiple hypothesis testing
title_full_unstemmed	Fast and covariate-adaptive method amplifies detection power in large-scale multiple hypothesis testing
title_sort	fast and covariate-adaptive method amplifies detection power in large-scale multiple hypothesis testing
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/857c63f9248a49b7a4152050747075ac
work_keys_str_mv	AT martinjzhang fastandcovariateadaptivemethodamplifiesdetectionpowerinlargescalemultiplehypothesistesting AT feixia fastandcovariateadaptivemethodamplifiesdetectionpowerinlargescalemultiplehypothesistesting AT jameszou fastandcovariateadaptivemethodamplifiesdetectionpowerinlargescalemultiplehypothesistesting
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Fast and covariate-adaptive method amplifies detection power in large-scale multiple hypothesis testing

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