Stabilization of p18 by deubiquitylase CYLD is pivotal for cell cycle progression and viral replication

Stabilization of p18 by deubiquitylase CYLD is pivotal for cell cycle progression and viral replication

Abstract p18 is a key negative regulator of cell cycle progression and mediates cell cycle arrest at the G1/S phase. Ubiquitination is the prime mechanism in regulating p18 protein abundance. However, so far no post- translational regulator, especially DUBs, has been identified to regulate the prote...

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Detalles Bibliográficos
Autores principales: Yueshuo Li, Feng Shi, Jianmin Hu, Longlong Xie, Lin Zhao, Min Tang, Xiangjian Luo, Mao Ye, Hui Zheng, Min Zhou, Na Liu, Ann M. Bode, Jia Fan, Jian Zhou, Qiang Gao, Shuangjian Qiu, Weizhong Wu, Xin Zhang, Weihua Liao, Ya Cao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Acceso en línea:https://doaj.org/article/85907f4c3e4044ed90ab1675dff51c6d
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https://doaj.org/article/85907f4c3e4044ed90ab1675dff51c6d

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