<named-content content-type="genus-species">Plasmodium berghei</named-content> K13 Mutations Mediate <italic toggle="yes">In Vivo</italic> Artemisinin Resistance That Is Reversed by Proteasome Inhibition

<named-content content-type="genus-species">Plasmodium berghei</named-content> K13 Mutations Mediate <italic toggle="yes">In Vivo</italic> Artemisinin Resistance That Is Reversed by Proteasome Inhibition

ABSTRACT The recent emergence of Plasmodium falciparum parasite resistance to the first line antimalarial drug artemisinin is of particular concern. Artemisinin resistance is primarily driven by mutations in the P. falciparum K13 protein, which enhance survival of early ring-stage parasites treated...

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Autores principales: Nelson V. Simwela, Barbara H. Stokes, Dana Aghabi, Matt Bogyo, David A. Fidock, Andrew P. Waters
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2020
Materias:
malaria
Plasmodium berghei
Plasmodium falciparum
artemisinin resistance
K13
gene editing
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/85aa674b6bf4474081ee9cbaad5abeea
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