IRE1α-XBP1 but not PERK inhibition exerts anti-tumor activity in osteosarcoma
Abstract Osteosarcoma (OS) is the most common primary malignant bone tumor. However, the therapeutic results of the advanced cases at the first visit were still extremely poor. Therefore, more effective therapeutic options based on molecular profiling of OS are needed. In this study, we investigated...
Saved in:
Main Authors: | Keita Sasa, Tsuyoshi Saito, Taisei Kurihara, Nobuhiko Hasegawa, Kei Sano, Daisuke Kubota, Keisuke Akaike, Taketo Okubo, Takuo Hayashi, Tatsuya Takagi, Takashi Yao, Muneaki Ishijima, Yoshiyuki Suehara |
---|---|
Format: | article |
Language: | EN |
Published: |
Springer
2021
|
Subjects: | |
Online Access: | https://doaj.org/article/85b9019b871845f2aaa55cdf3b4a35f5 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
The IRE1/XBP1 signaling axis promotes skeletal muscle regeneration through a cell non-autonomous mechanism
by: Anirban Roy, et al.
Published: (2021) -
A Human IRE1 Inhibitor Blocks the Unfolded Protein Response in the Pathogenic Fungus <named-content content-type="genus-species">Aspergillus fumigatus</named-content> and Suggests Noncanonical Functions within the Pathway
by: José P. Guirao-Abad, et al.
Published: (2020) -
Icariin inhibits the expression of IL-1β, IL-6 and TNF-α induced by OGD/R through the IRE1/XBP1s pathway in microglia
by: Zhen-Tao Mo, et al.
Published: (2021) -
Downregulation of microRNA-512-3p enhances the viability and suppresses the apoptosis of vascular endothelial cells, alleviates autophagy and endoplasmic reticulum stress as well as represses atherosclerotic lesions in atherosclerosis by adjusting spliced/unspliced ratio of X-box binding protein 1 (XBP-1S/XBP-1U)
by: Peipei Ge, et al.
Published: (2021) -
Tratamiento adyuvante (Conpadri I) en osteosarcoma infantil (Valdivia 1980-1990)
by: Zolezzi R,Paola, et al.
Published: (1992)