Deregulated Gab2 phosphorylation mediates aberrant AKT and STAT3 signaling upon PIK3R1 loss in ovarian cancer

Loss of PIK3R1 in ovarian cancer is a common event, which provides opportunities for therapeutic intervention. Here, the authors show that the STAT3 and AKT signaling pathways are activated upon PIK3R1 loss and that, in mice, inhibitors of these pathways could block tumorigenesis.

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Autores principales:	Xinran Li, Victor C. Y. Mak, Yuan Zhou, Chao Wang, Esther S. Y. Wong, Rakesh Sharma, Yiling Lu, Annie N. Y. Cheung, Gordon B. Mills, Lydia W. T. Cheung
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/85e4150d1ad2485d83cd05457232c1ef
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:85e4150d1ad2485d83cd05457232c1ef2021-12-02T15:35:30ZDeregulated Gab2 phosphorylation mediates aberrant AKT and STAT3 signaling upon PIK3R1 loss in ovarian cancer10.1038/s41467-019-08574-72041-1723https://doaj.org/article/85e4150d1ad2485d83cd05457232c1ef2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08574-7https://doaj.org/toc/2041-1723Loss of PIK3R1 in ovarian cancer is a common event, which provides opportunities for therapeutic intervention. Here, the authors show that the STAT3 and AKT signaling pathways are activated upon PIK3R1 loss and that, in mice, inhibitors of these pathways could block tumorigenesis.Xinran LiVictor C. Y. MakYuan ZhouChao WangEsther S. Y. WongRakesh SharmaYiling LuAnnie N. Y. CheungGordon B. MillsLydia W. T. CheungNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xinran Li Victor C. Y. Mak Yuan Zhou Chao Wang Esther S. Y. Wong Rakesh Sharma Yiling Lu Annie N. Y. Cheung Gordon B. Mills Lydia W. T. Cheung Deregulated Gab2 phosphorylation mediates aberrant AKT and STAT3 signaling upon PIK3R1 loss in ovarian cancer
description	Loss of PIK3R1 in ovarian cancer is a common event, which provides opportunities for therapeutic intervention. Here, the authors show that the STAT3 and AKT signaling pathways are activated upon PIK3R1 loss and that, in mice, inhibitors of these pathways could block tumorigenesis.
format	article
author	Xinran Li Victor C. Y. Mak Yuan Zhou Chao Wang Esther S. Y. Wong Rakesh Sharma Yiling Lu Annie N. Y. Cheung Gordon B. Mills Lydia W. T. Cheung
author_facet	Xinran Li Victor C. Y. Mak Yuan Zhou Chao Wang Esther S. Y. Wong Rakesh Sharma Yiling Lu Annie N. Y. Cheung Gordon B. Mills Lydia W. T. Cheung
author_sort	Xinran Li
title	Deregulated Gab2 phosphorylation mediates aberrant AKT and STAT3 signaling upon PIK3R1 loss in ovarian cancer
title_short	Deregulated Gab2 phosphorylation mediates aberrant AKT and STAT3 signaling upon PIK3R1 loss in ovarian cancer
title_full	Deregulated Gab2 phosphorylation mediates aberrant AKT and STAT3 signaling upon PIK3R1 loss in ovarian cancer
title_fullStr	Deregulated Gab2 phosphorylation mediates aberrant AKT and STAT3 signaling upon PIK3R1 loss in ovarian cancer
title_full_unstemmed	Deregulated Gab2 phosphorylation mediates aberrant AKT and STAT3 signaling upon PIK3R1 loss in ovarian cancer
title_sort	deregulated gab2 phosphorylation mediates aberrant akt and stat3 signaling upon pik3r1 loss in ovarian cancer
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/85e4150d1ad2485d83cd05457232c1ef
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Deregulated Gab2 phosphorylation mediates aberrant AKT and STAT3 signaling upon PIK3R1 loss in ovarian cancer

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