Defining a conformational ensemble that directs activation of PPARγ

Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor. Here the authors provide insights into PPARγ activation by combining fluorine (19F) NMR and molecular dynamics simulations to characterize the nuclear receptor conformational ensemble in solution and the response of this...

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Autores principales:	Ian M. Chrisman, Michelle D. Nemetchek, Ian Mitchelle S. de Vera, Jinsai Shang, Zahra Heidari, Yanan Long, Hermes Reyes-Caballero, Rodrigo Galindo-Murillo, Thomas E. Cheatham, Anne-Laure Blayo, Youseung Shin, Jakob Fuhrmann, Patrick R. Griffin, Theodore M. Kamenecka, Douglas J. Kojetin, Travis S. Hughes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/85e8ea413a844fe895eaaf28a09a3b89
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:85e8ea413a844fe895eaaf28a09a3b892021-12-02T17:32:19ZDefining a conformational ensemble that directs activation of PPARγ10.1038/s41467-018-04176-x2041-1723https://doaj.org/article/85e8ea413a844fe895eaaf28a09a3b892018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04176-xhttps://doaj.org/toc/2041-1723Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor. Here the authors provide insights into PPARγ activation by combining fluorine (19F) NMR and molecular dynamics simulations to characterize the nuclear receptor conformational ensemble in solution and the response of this ensemble to ligand and coregulatory peptide binding.Ian M. ChrismanMichelle D. NemetchekIan Mitchelle S. de VeraJinsai ShangZahra HeidariYanan LongHermes Reyes-CaballeroRodrigo Galindo-MurilloThomas E. CheathamAnne-Laure BlayoYouseung ShinJakob FuhrmannPatrick R. GriffinTheodore M. KameneckaDouglas J. KojetinTravis S. HughesNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ian M. Chrisman Michelle D. Nemetchek Ian Mitchelle S. de Vera Jinsai Shang Zahra Heidari Yanan Long Hermes Reyes-Caballero Rodrigo Galindo-Murillo Thomas E. Cheatham Anne-Laure Blayo Youseung Shin Jakob Fuhrmann Patrick R. Griffin Theodore M. Kamenecka Douglas J. Kojetin Travis S. Hughes Defining a conformational ensemble that directs activation of PPARγ
description	Peroxisome proliferator-activated receptor gamma (PPARγ) is a nuclear receptor. Here the authors provide insights into PPARγ activation by combining fluorine (19F) NMR and molecular dynamics simulations to characterize the nuclear receptor conformational ensemble in solution and the response of this ensemble to ligand and coregulatory peptide binding.
format	article
author	Ian M. Chrisman Michelle D. Nemetchek Ian Mitchelle S. de Vera Jinsai Shang Zahra Heidari Yanan Long Hermes Reyes-Caballero Rodrigo Galindo-Murillo Thomas E. Cheatham Anne-Laure Blayo Youseung Shin Jakob Fuhrmann Patrick R. Griffin Theodore M. Kamenecka Douglas J. Kojetin Travis S. Hughes
author_facet	Ian M. Chrisman Michelle D. Nemetchek Ian Mitchelle S. de Vera Jinsai Shang Zahra Heidari Yanan Long Hermes Reyes-Caballero Rodrigo Galindo-Murillo Thomas E. Cheatham Anne-Laure Blayo Youseung Shin Jakob Fuhrmann Patrick R. Griffin Theodore M. Kamenecka Douglas J. Kojetin Travis S. Hughes
author_sort	Ian M. Chrisman
title	Defining a conformational ensemble that directs activation of PPARγ
title_short	Defining a conformational ensemble that directs activation of PPARγ
title_full	Defining a conformational ensemble that directs activation of PPARγ
title_fullStr	Defining a conformational ensemble that directs activation of PPARγ
title_full_unstemmed	Defining a conformational ensemble that directs activation of PPARγ
title_sort	defining a conformational ensemble that directs activation of pparγ
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/85e8ea413a844fe895eaaf28a09a3b89
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Defining a conformational ensemble that directs activation of PPARγ

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