Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells

Mutations in BRCA1 and BRCA2 render a cancer cell hypersensitive to PARP inhibitors but they can acquire resistance and relapse. Here the authors find that PARP inhibition leads to replication fork instability, cytokinesis failure and cell death, aiding our understanding of how inhibition leads to c...

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Autores principales:	Pepijn M. Schoonen, Francien Talens, Colin Stok, Ewa Gogola, Anne Margriet Heijink, Peter Bouwman, Floris Foijer, Madalena Tarsounas, Sohvi Blatter, Jos Jonkers, Sven Rottenberg, Marcel A. T. M. van Vugt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/86272fb47c1c44e091878a6dfa6f26de
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spelling	oai:doaj.org-article:86272fb47c1c44e091878a6dfa6f26de2021-12-02T17:06:10ZProgression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells10.1038/ncomms159812041-1723https://doaj.org/article/86272fb47c1c44e091878a6dfa6f26de2017-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms15981https://doaj.org/toc/2041-1723Mutations in BRCA1 and BRCA2 render a cancer cell hypersensitive to PARP inhibitors but they can acquire resistance and relapse. Here the authors find that PARP inhibition leads to replication fork instability, cytokinesis failure and cell death, aiding our understanding of how inhibition leads to cytotoxic outcomes.Pepijn M. SchoonenFrancien TalensColin StokEwa GogolaAnne Margriet HeijinkPeter BouwmanFloris FoijerMadalena TarsounasSohvi BlatterJos JonkersSven RottenbergMarcel A. T. M. van VugtNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pepijn M. Schoonen Francien Talens Colin Stok Ewa Gogola Anne Margriet Heijink Peter Bouwman Floris Foijer Madalena Tarsounas Sohvi Blatter Jos Jonkers Sven Rottenberg Marcel A. T. M. van Vugt Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells
description	Mutations in BRCA1 and BRCA2 render a cancer cell hypersensitive to PARP inhibitors but they can acquire resistance and relapse. Here the authors find that PARP inhibition leads to replication fork instability, cytokinesis failure and cell death, aiding our understanding of how inhibition leads to cytotoxic outcomes.
format	article
author	Pepijn M. Schoonen Francien Talens Colin Stok Ewa Gogola Anne Margriet Heijink Peter Bouwman Floris Foijer Madalena Tarsounas Sohvi Blatter Jos Jonkers Sven Rottenberg Marcel A. T. M. van Vugt
author_facet	Pepijn M. Schoonen Francien Talens Colin Stok Ewa Gogola Anne Margriet Heijink Peter Bouwman Floris Foijer Madalena Tarsounas Sohvi Blatter Jos Jonkers Sven Rottenberg Marcel A. T. M. van Vugt
author_sort	Pepijn M. Schoonen
title	Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells
title_short	Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells
title_full	Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells
title_fullStr	Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells
title_full_unstemmed	Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells
title_sort	progression through mitosis promotes parp inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/86272fb47c1c44e091878a6dfa6f26de
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Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells

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