Transcriptional effects of copy number alterations in a large set of human cancers

by Arkajyoti Bhattacharya, Rico D. Bense, Carlos G. Urzúa-Traslaviña, Elisabeth G. E. de Vries, Marcel A. T. M. van Vugt, Rudolf S. N. Fehrmann
Published 2020

BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity

by Anne Margriet Heijink, Francien Talens, Lucas T. Jae, Stephanie E. van Gijn, Rudolf S. N. Fehrmann, Thijn R. Brummelkamp, Marcel A. T. M. van Vugt
Published 2019

Improving gene function predictions using independent transcriptional components

by Carlos G. Urzúa-Traslaviña, Vincent C. Leeuwenburgh, Arkajyoti Bhattacharya, Stefan Loipfinger, Marcel A. T. M. van Vugt, Elisabeth G. E. de Vries, Rudolf S. N. Fehrmann
Published 2021

RIF1 promotes replication fork protection and efficient restart to maintain genome stability

by Chirantani Mukherjee, Vivek Tripathi, Eleni Maria Manolika, Anne Margriet Heijink, Giulia Ricci, Sarra Merzouk, H. Rudolf de Boer, Jeroen Demmers, Marcel A. T. M. van Vugt, Arnab Ray Chaudhuri
Published 2019

Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells

by Pepijn M. Schoonen, Francien Talens, Colin Stok, Ewa Gogola, Anne Margriet Heijink, Peter Bouwman, Floris Foijer, Madalena Tarsounas, Sohvi Blatter, Jos Jonkers, Sven Rottenberg, Marcel A. T. M. van Vugt
Published 2017

A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint.

by Marcel A T M van Vugt, Alexandra K Gardino, Rune Linding, Gerard J Ostheimer, H Christian Reinhardt, Shao-En Ong, Chris S Tan, Hua Miao, Susan M Keezer, Jeijin Li, Tony Pawson, Timothy A Lewis, Steven A Carr, Stephen J Smerdon, Thijn R Brummelkamp, Michael B Yaffe
Published 2010

The H3.3K27M oncohistone affects replication stress outcome and provokes genomic instability in pediatric glioma.

by Irena Bočkaj, Tosca E I Martini, Eduardo S de Camargo Magalhães, Petra L Bakker, Tiny G J Meeuwsen-de Boer, Inna Armandari, Saskia L Meuleman, Marin T Mondria, Colin Stok, Yannick P Kok, Bjorn Bakker, René Wardenaar, Jonas Seiler, Mathilde J C Broekhuis, Hilda van den Bos, Diana C J Spierings, Femke C A Ringnalda, Hans Clevers, Ulrich Schüller, Marcel A T M van Vugt, Floris Foijer, Sophia W M Bruggeman
Published 2021

The H3.3K27M oncohistone affects replication stress outcome and provokes genomic instability in pediatric glioma

by Irena Bočkaj, Tosca E. I. Martini, Eduardo S. de Camargo Magalhães, Petra L. Bakker, Tiny G. J. Meeuwsen-de Boer, Inna Armandari, Saskia L. Meuleman, Marin T. Mondria, Colin Stok, Yannick P. Kok, Bjorn Bakker, René Wardenaar, Jonas Seiler, Mathilde J. C. Broekhuis, Hilda van den Bos, Diana C. J. Spierings, Femke C. A. Ringnalda, Hans Clevers, Ulrich Schüller, Marcel A. T. M. van Vugt, Floris Foijer, Sophia W. M. Bruggeman
Published 2021