Decreased NK-cell tumour immunosurveillance consequent to JAK inhibition enhances metastasis in breast cancer models

JAK inhibitors are currently undergoing evaluation in clinical trials for advanced breast cancer. Here, the authors show that JAK pathway inhibition increases metastasis in mouse models of breast cancer by impairing NK anti-tumour activity and that these side effects can be overcome by addition of I...

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Bibliographic Details
Main Authors: Alessia Bottos, Dagmar Gotthardt, Jason W. Gill, Albana Gattelli, Anna Frei, Alexandar Tzankov, Veronika Sexl, Aleksandra Wodnar-Filipowicz, Nancy E. Hynes
Format: article
Language:EN
Published: Nature Portfolio 2016
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Online Access:https://doaj.org/article/86420aae63434acfa4d1039c29037e97
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