Decreased NK-cell tumour immunosurveillance consequent to JAK inhibition enhances metastasis in breast cancer models

JAK inhibitors are currently undergoing evaluation in clinical trials for advanced breast cancer. Here, the authors show that JAK pathway inhibition increases metastasis in mouse models of breast cancer by impairing NK anti-tumour activity and that these side effects can be overcome by addition of I...

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Autores principales:	Alessia Bottos, Dagmar Gotthardt, Jason W. Gill, Albana Gattelli, Anna Frei, Alexandar Tzankov, Veronika Sexl, Aleksandra Wodnar-Filipowicz, Nancy E. Hynes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/86420aae63434acfa4d1039c29037e97
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spelling	oai:doaj.org-article:86420aae63434acfa4d1039c29037e972021-12-02T17:31:34ZDecreased NK-cell tumour immunosurveillance consequent to JAK inhibition enhances metastasis in breast cancer models10.1038/ncomms122582041-1723https://doaj.org/article/86420aae63434acfa4d1039c29037e972016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12258https://doaj.org/toc/2041-1723JAK inhibitors are currently undergoing evaluation in clinical trials for advanced breast cancer. Here, the authors show that JAK pathway inhibition increases metastasis in mouse models of breast cancer by impairing NK anti-tumour activity and that these side effects can be overcome by addition of IL-15.Alessia BottosDagmar GotthardtJason W. GillAlbana GattelliAnna FreiAlexandar TzankovVeronika SexlAleksandra Wodnar-FilipowiczNancy E. HynesNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alessia Bottos Dagmar Gotthardt Jason W. Gill Albana Gattelli Anna Frei Alexandar Tzankov Veronika Sexl Aleksandra Wodnar-Filipowicz Nancy E. Hynes Decreased NK-cell tumour immunosurveillance consequent to JAK inhibition enhances metastasis in breast cancer models
description	JAK inhibitors are currently undergoing evaluation in clinical trials for advanced breast cancer. Here, the authors show that JAK pathway inhibition increases metastasis in mouse models of breast cancer by impairing NK anti-tumour activity and that these side effects can be overcome by addition of IL-15.
format	article
author	Alessia Bottos Dagmar Gotthardt Jason W. Gill Albana Gattelli Anna Frei Alexandar Tzankov Veronika Sexl Aleksandra Wodnar-Filipowicz Nancy E. Hynes
author_facet	Alessia Bottos Dagmar Gotthardt Jason W. Gill Albana Gattelli Anna Frei Alexandar Tzankov Veronika Sexl Aleksandra Wodnar-Filipowicz Nancy E. Hynes
author_sort	Alessia Bottos
title	Decreased NK-cell tumour immunosurveillance consequent to JAK inhibition enhances metastasis in breast cancer models
title_short	Decreased NK-cell tumour immunosurveillance consequent to JAK inhibition enhances metastasis in breast cancer models
title_full	Decreased NK-cell tumour immunosurveillance consequent to JAK inhibition enhances metastasis in breast cancer models
title_fullStr	Decreased NK-cell tumour immunosurveillance consequent to JAK inhibition enhances metastasis in breast cancer models
title_full_unstemmed	Decreased NK-cell tumour immunosurveillance consequent to JAK inhibition enhances metastasis in breast cancer models
title_sort	decreased nk-cell tumour immunosurveillance consequent to jak inhibition enhances metastasis in breast cancer models
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/86420aae63434acfa4d1039c29037e97
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Decreased NK-cell tumour immunosurveillance consequent to JAK inhibition enhances metastasis in breast cancer models

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