Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis

Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis

Pancreatitis often develops as a consequence of ductal obstruction. Here, the authors show that bicarbonate ions initiate the release of neutrophil extracellular traps (NETs) that form pancreatic ductal aggregates and occlude the ducts, thereby driving pancreatitis in mice and humans.

Guardado en:
Detalles Bibliográficos
Autores principales: Moritz Leppkes, Christian Maueröder, Sebastian Hirth, Stefanie Nowecki, Claudia Günther, Ulrike Billmeier, Susanne Paulus, Mona Biermann, Luis E. Munoz, Markus Hoffmann, Dane Wildner, Andrew L. Croxford, Ari Waisman, Kerri Mowen, Dieter E. Jenne, Veit Krenn, Julia Mayerle, Markus M. Lerch, Georg Schett, Stefan Wirtz, Markus F. Neurath, Martin Herrmann, Christoph Becker
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/8649b3e8245b4fed8b30b9961760de6f
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Internet

https://doaj.org/article/8649b3e8245b4fed8b30b9961760de6f

Ejemplares similares