Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis

Pancreatitis often develops as a consequence of ductal obstruction. Here, the authors show that bicarbonate ions initiate the release of neutrophil extracellular traps (NETs) that form pancreatic ductal aggregates and occlude the ducts, thereby driving pancreatitis in mice and humans.

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Autores principales:	Moritz Leppkes, Christian Maueröder, Sebastian Hirth, Stefanie Nowecki, Claudia Günther, Ulrike Billmeier, Susanne Paulus, Mona Biermann, Luis E. Munoz, Markus Hoffmann, Dane Wildner, Andrew L. Croxford, Ari Waisman, Kerri Mowen, Dieter E. Jenne, Veit Krenn, Julia Mayerle, Markus M. Lerch, Georg Schett, Stefan Wirtz, Markus F. Neurath, Martin Herrmann, Christoph Becker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8649b3e8245b4fed8b30b9961760de6f
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spelling	oai:doaj.org-article:8649b3e8245b4fed8b30b9961760de6f2021-12-02T16:49:58ZExternalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis10.1038/ncomms109732041-1723https://doaj.org/article/8649b3e8245b4fed8b30b9961760de6f2016-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms10973https://doaj.org/toc/2041-1723Pancreatitis often develops as a consequence of ductal obstruction. Here, the authors show that bicarbonate ions initiate the release of neutrophil extracellular traps (NETs) that form pancreatic ductal aggregates and occlude the ducts, thereby driving pancreatitis in mice and humans.Moritz LeppkesChristian MaueröderSebastian HirthStefanie NoweckiClaudia GüntherUlrike BillmeierSusanne PaulusMona BiermannLuis E. MunozMarkus HoffmannDane WildnerAndrew L. CroxfordAri WaismanKerri MowenDieter E. JenneVeit KrennJulia MayerleMarkus M. LerchGeorg SchettStefan WirtzMarkus F. NeurathMartin HerrmannChristoph BeckerNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Moritz Leppkes Christian Maueröder Sebastian Hirth Stefanie Nowecki Claudia Günther Ulrike Billmeier Susanne Paulus Mona Biermann Luis E. Munoz Markus Hoffmann Dane Wildner Andrew L. Croxford Ari Waisman Kerri Mowen Dieter E. Jenne Veit Krenn Julia Mayerle Markus M. Lerch Georg Schett Stefan Wirtz Markus F. Neurath Martin Herrmann Christoph Becker Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis
description	Pancreatitis often develops as a consequence of ductal obstruction. Here, the authors show that bicarbonate ions initiate the release of neutrophil extracellular traps (NETs) that form pancreatic ductal aggregates and occlude the ducts, thereby driving pancreatitis in mice and humans.
format	article
author	Moritz Leppkes Christian Maueröder Sebastian Hirth Stefanie Nowecki Claudia Günther Ulrike Billmeier Susanne Paulus Mona Biermann Luis E. Munoz Markus Hoffmann Dane Wildner Andrew L. Croxford Ari Waisman Kerri Mowen Dieter E. Jenne Veit Krenn Julia Mayerle Markus M. Lerch Georg Schett Stefan Wirtz Markus F. Neurath Martin Herrmann Christoph Becker
author_facet	Moritz Leppkes Christian Maueröder Sebastian Hirth Stefanie Nowecki Claudia Günther Ulrike Billmeier Susanne Paulus Mona Biermann Luis E. Munoz Markus Hoffmann Dane Wildner Andrew L. Croxford Ari Waisman Kerri Mowen Dieter E. Jenne Veit Krenn Julia Mayerle Markus M. Lerch Georg Schett Stefan Wirtz Markus F. Neurath Martin Herrmann Christoph Becker
author_sort	Moritz Leppkes
title	Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis
title_short	Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis
title_full	Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis
title_fullStr	Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis
title_full_unstemmed	Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis
title_sort	externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/8649b3e8245b4fed8b30b9961760de6f
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Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis

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