Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis

Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis

Pancreatitis often develops as a consequence of ductal obstruction. Here, the authors show that bicarbonate ions initiate the release of neutrophil extracellular traps (NETs) that form pancreatic ductal aggregates and occlude the ducts, thereby driving pancreatitis in mice and humans.

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Bibliographic Details
Main Authors: Moritz Leppkes, Christian Maueröder, Sebastian Hirth, Stefanie Nowecki, Claudia Günther, Ulrike Billmeier, Susanne Paulus, Mona Biermann, Luis E. Munoz, Markus Hoffmann, Dane Wildner, Andrew L. Croxford, Ari Waisman, Kerri Mowen, Dieter E. Jenne, Veit Krenn, Julia Mayerle, Markus M. Lerch, Georg Schett, Stefan Wirtz, Markus F. Neurath, Martin Herrmann, Christoph Becker
Format: article
Language:EN
Published: Nature Portfolio 2016
Subjects:
Science
Q
Online Access:https://doaj.org/article/8649b3e8245b4fed8b30b9961760de6f
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Internet

https://doaj.org/article/8649b3e8245b4fed8b30b9961760de6f

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