Clinically Relevant Mutations of Mycobacterial GatCAB Inform Regulation of Translational Fidelity

ABSTRACT Most bacteria employ a two-step indirect tRNA aminoacylation pathway for the synthesis of aminoacylated tRNAGln and tRNAAsn. The heterotrimeric enzyme GatCAB performs a critical amidotransferase reaction in the second step of this pathway. We have previously demonstrated in mycobacteria tha...

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Autores principales: Yang-Yang Li, Rong-Jun Cai, Jia-Ying Yang, Tamara L. Hendrickson, Ye Xiang, Babak Javid
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2021
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Acceso en línea:https://doaj.org/article/8667954f6d2a4905887e75541bdb280d
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