Herpes simplex virus blocks host transcription termination via the bimodal activities of ICP27

Herpes simplex virus blocks host transcription termination via the bimodal activities of ICP27

Herpes simplex virus-1 (HSV-1) infection disrupts transcription termination (DoTT) of host genes, but underlying mechanisms are unclear. Here, Wang et al. show that the HSV-1 immediate early protein ICP27 induces DoTT through interaction with the mRNA 3’ processing factor CPSF and disruption of the...

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Bibliographic Details
Main Authors: Xiuye Wang, Thomas Hennig, Adam W. Whisnant, Florian Erhard, Bhupesh K. Prusty, Caroline C. Friedel, Elmira Forouzmand, William Hu, Luke Erber, Yue Chen, Rozanne M. Sandri-Goldin, Lars Dölken, Yongsheng Shi
Format: article
Language:EN
Published: Nature Portfolio 2020
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Science
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Online Access:https://doaj.org/article/86795a19df404ef6a9b5cb941f4f5451
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https://doaj.org/article/86795a19df404ef6a9b5cb941f4f5451

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