Herpes simplex virus blocks host transcription termination via the bimodal activities of ICP27

Herpes simplex virus-1 (HSV-1) infection disrupts transcription termination (DoTT) of host genes, but underlying mechanisms are unclear. Here, Wang et al. show that the HSV-1 immediate early protein ICP27 induces DoTT through interaction with the mRNA 3’ processing factor CPSF and disruption of the...

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Autores principales:	Xiuye Wang, Thomas Hennig, Adam W. Whisnant, Florian Erhard, Bhupesh K. Prusty, Caroline C. Friedel, Elmira Forouzmand, William Hu, Luke Erber, Yue Chen, Rozanne M. Sandri-Goldin, Lars Dölken, Yongsheng Shi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/86795a19df404ef6a9b5cb941f4f5451
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spelling	oai:doaj.org-article:86795a19df404ef6a9b5cb941f4f54512021-12-02T17:33:12ZHerpes simplex virus blocks host transcription termination via the bimodal activities of ICP2710.1038/s41467-019-14109-x2041-1723https://doaj.org/article/86795a19df404ef6a9b5cb941f4f54512020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14109-xhttps://doaj.org/toc/2041-1723Herpes simplex virus-1 (HSV-1) infection disrupts transcription termination (DoTT) of host genes, but underlying mechanisms are unclear. Here, Wang et al. show that the HSV-1 immediate early protein ICP27 induces DoTT through interaction with the mRNA 3’ processing factor CPSF and disruption of the processing complex.Xiuye WangThomas HennigAdam W. WhisnantFlorian ErhardBhupesh K. PrustyCaroline C. FriedelElmira ForouzmandWilliam HuLuke ErberYue ChenRozanne M. Sandri-GoldinLars DölkenYongsheng ShiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiuye Wang Thomas Hennig Adam W. Whisnant Florian Erhard Bhupesh K. Prusty Caroline C. Friedel Elmira Forouzmand William Hu Luke Erber Yue Chen Rozanne M. Sandri-Goldin Lars Dölken Yongsheng Shi Herpes simplex virus blocks host transcription termination via the bimodal activities of ICP27
description	Herpes simplex virus-1 (HSV-1) infection disrupts transcription termination (DoTT) of host genes, but underlying mechanisms are unclear. Here, Wang et al. show that the HSV-1 immediate early protein ICP27 induces DoTT through interaction with the mRNA 3’ processing factor CPSF and disruption of the processing complex.
format	article
author	Xiuye Wang Thomas Hennig Adam W. Whisnant Florian Erhard Bhupesh K. Prusty Caroline C. Friedel Elmira Forouzmand William Hu Luke Erber Yue Chen Rozanne M. Sandri-Goldin Lars Dölken Yongsheng Shi
author_facet	Xiuye Wang Thomas Hennig Adam W. Whisnant Florian Erhard Bhupesh K. Prusty Caroline C. Friedel Elmira Forouzmand William Hu Luke Erber Yue Chen Rozanne M. Sandri-Goldin Lars Dölken Yongsheng Shi
author_sort	Xiuye Wang
title	Herpes simplex virus blocks host transcription termination via the bimodal activities of ICP27
title_short	Herpes simplex virus blocks host transcription termination via the bimodal activities of ICP27
title_full	Herpes simplex virus blocks host transcription termination via the bimodal activities of ICP27
title_fullStr	Herpes simplex virus blocks host transcription termination via the bimodal activities of ICP27
title_full_unstemmed	Herpes simplex virus blocks host transcription termination via the bimodal activities of ICP27
title_sort	herpes simplex virus blocks host transcription termination via the bimodal activities of icp27
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/86795a19df404ef6a9b5cb941f4f5451
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Herpes simplex virus blocks host transcription termination via the bimodal activities of ICP27

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