Juxtacrine Activity of Estrogen Receptor α in Uterine Stromal Cells is Necessary for Estrogen-Induced Epithelial Cell Proliferation

Abstract Aberrant regulation of uterine cell growth can lead to endometrial cancer and infertility. To understand the molecular mechanisms of estrogen-induced uterine cell growth, we removed the estrogen receptor α (Esr1) from mouse uterine stromal cells, where the embryo is implanted during pregnan...

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Autores principales:	Wipawee Winuthayanon, Sydney L. Lierz, Karena C. Delarosa, Skylar R. Sampels, Lauren J. Donoghue, Sylvia C. Hewitt, Kenneth S. Korach
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8688e9eb254b477c9b007249a18d3a50
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spelling	oai:doaj.org-article:8688e9eb254b477c9b007249a18d3a502021-12-02T11:52:24ZJuxtacrine Activity of Estrogen Receptor α in Uterine Stromal Cells is Necessary for Estrogen-Induced Epithelial Cell Proliferation10.1038/s41598-017-07728-12045-2322https://doaj.org/article/8688e9eb254b477c9b007249a18d3a502017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07728-1https://doaj.org/toc/2045-2322Abstract Aberrant regulation of uterine cell growth can lead to endometrial cancer and infertility. To understand the molecular mechanisms of estrogen-induced uterine cell growth, we removed the estrogen receptor α (Esr1) from mouse uterine stromal cells, where the embryo is implanted during pregnancy. Without ESR1 in neighboring stroma cells, epithelial cells that line the inside of the uterus are unable to grow due to a lack of growth factors secreted from adjacent stromal cells. Moreover, loss of stromal ESR1 caused mice to deliver fewer pups due in part due to inability of some embryos to implant in the uterus, indicating that stromal ESR1 is crucial for uterine cell growth and pregnancy.Wipawee WinuthayanonSydney L. LierzKarena C. DelarosaSkylar R. SampelsLauren J. DonoghueSylvia C. HewittKenneth S. KorachNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wipawee Winuthayanon Sydney L. Lierz Karena C. Delarosa Skylar R. Sampels Lauren J. Donoghue Sylvia C. Hewitt Kenneth S. Korach Juxtacrine Activity of Estrogen Receptor α in Uterine Stromal Cells is Necessary for Estrogen-Induced Epithelial Cell Proliferation
description	Abstract Aberrant regulation of uterine cell growth can lead to endometrial cancer and infertility. To understand the molecular mechanisms of estrogen-induced uterine cell growth, we removed the estrogen receptor α (Esr1) from mouse uterine stromal cells, where the embryo is implanted during pregnancy. Without ESR1 in neighboring stroma cells, epithelial cells that line the inside of the uterus are unable to grow due to a lack of growth factors secreted from adjacent stromal cells. Moreover, loss of stromal ESR1 caused mice to deliver fewer pups due in part due to inability of some embryos to implant in the uterus, indicating that stromal ESR1 is crucial for uterine cell growth and pregnancy.
format	article
author	Wipawee Winuthayanon Sydney L. Lierz Karena C. Delarosa Skylar R. Sampels Lauren J. Donoghue Sylvia C. Hewitt Kenneth S. Korach
author_facet	Wipawee Winuthayanon Sydney L. Lierz Karena C. Delarosa Skylar R. Sampels Lauren J. Donoghue Sylvia C. Hewitt Kenneth S. Korach
author_sort	Wipawee Winuthayanon
title	Juxtacrine Activity of Estrogen Receptor α in Uterine Stromal Cells is Necessary for Estrogen-Induced Epithelial Cell Proliferation
title_short	Juxtacrine Activity of Estrogen Receptor α in Uterine Stromal Cells is Necessary for Estrogen-Induced Epithelial Cell Proliferation
title_full	Juxtacrine Activity of Estrogen Receptor α in Uterine Stromal Cells is Necessary for Estrogen-Induced Epithelial Cell Proliferation
title_fullStr	Juxtacrine Activity of Estrogen Receptor α in Uterine Stromal Cells is Necessary for Estrogen-Induced Epithelial Cell Proliferation
title_full_unstemmed	Juxtacrine Activity of Estrogen Receptor α in Uterine Stromal Cells is Necessary for Estrogen-Induced Epithelial Cell Proliferation
title_sort	juxtacrine activity of estrogen receptor α in uterine stromal cells is necessary for estrogen-induced epithelial cell proliferation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8688e9eb254b477c9b007249a18d3a50
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Juxtacrine Activity of Estrogen Receptor α in Uterine Stromal Cells is Necessary for Estrogen-Induced Epithelial Cell Proliferation

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