Polyanions provide selective control of APC/C interactions with the activator subunit

Activation of APC/C depends on transient interactions with an activator subunit. Here, the authors show that cellular polyanions trigger APC/C-activator dissociation and that high-affinity substrates block this effect, suggesting that substrate availability controls APC/C-activator binding.

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Autores principales: Arda Mizrak, David O. Morgan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/869fdb2adcb8456499a4ef87da848460
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