Polyanions provide selective control of APC/C interactions with the activator subunit

Activation of APC/C depends on transient interactions with an activator subunit. Here, the authors show that cellular polyanions trigger APC/C-activator dissociation and that high-affinity substrates block this effect, suggesting that substrate availability controls APC/C-activator binding.

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Detalles Bibliográficos
Autores principales:	Arda Mizrak, David O. Morgan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/869fdb2adcb8456499a4ef87da848460
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spelling	oai:doaj.org-article:869fdb2adcb8456499a4ef87da8484602021-12-02T15:35:49ZPolyanions provide selective control of APC/C interactions with the activator subunit10.1038/s41467-019-13864-12041-1723https://doaj.org/article/869fdb2adcb8456499a4ef87da8484602019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13864-1https://doaj.org/toc/2041-1723Activation of APC/C depends on transient interactions with an activator subunit. Here, the authors show that cellular polyanions trigger APC/C-activator dissociation and that high-affinity substrates block this effect, suggesting that substrate availability controls APC/C-activator binding.Arda MizrakDavid O. MorganNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Arda Mizrak David O. Morgan Polyanions provide selective control of APC/C interactions with the activator subunit
description	Activation of APC/C depends on transient interactions with an activator subunit. Here, the authors show that cellular polyanions trigger APC/C-activator dissociation and that high-affinity substrates block this effect, suggesting that substrate availability controls APC/C-activator binding.
format	article
author	Arda Mizrak David O. Morgan
author_facet	Arda Mizrak David O. Morgan
author_sort	Arda Mizrak
title	Polyanions provide selective control of APC/C interactions with the activator subunit
title_short	Polyanions provide selective control of APC/C interactions with the activator subunit
title_full	Polyanions provide selective control of APC/C interactions with the activator subunit
title_fullStr	Polyanions provide selective control of APC/C interactions with the activator subunit
title_full_unstemmed	Polyanions provide selective control of APC/C interactions with the activator subunit
title_sort	polyanions provide selective control of apc/c interactions with the activator subunit
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/869fdb2adcb8456499a4ef87da848460
work_keys_str_mv	AT ardamizrak polyanionsprovideselectivecontrolofapccinteractionswiththeactivatorsubunit AT davidomorgan polyanionsprovideselectivecontrolofapccinteractionswiththeactivatorsubunit
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Polyanions provide selective control of APC/C interactions with the activator subunit

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