Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities

Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities

In tumors, hundreds of genes can undergo loss of heterozygosity (LOH). Here, the authors investigate the potential for this LOH as a class of non-driver cancer vulnerabilities.

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Auteurs principaux: Caitlin A. Nichols, William J. Gibson, Meredith S. Brown, Jack A. Kosmicki, John P. Busanovich, Hope Wei, Laura M. Urbanski, Naomi Curimjee, Ashton C. Berger, Galen F. Gao, Andrew D. Cherniack, Sirano Dhe-Paganon, Brenton R. Paolella, Rameen Beroukhim
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Science
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Accès en ligne:https://doaj.org/article/86a1e531ffce47339d04b2ee5dc0b8e0
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https://doaj.org/article/86a1e531ffce47339d04b2ee5dc0b8e0

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