Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities

Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities

In tumors, hundreds of genes can undergo loss of heterozygosity (LOH). Here, the authors investigate the potential for this LOH as a class of non-driver cancer vulnerabilities.

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Detalles Bibliográficos
Autores principales: Caitlin A. Nichols, William J. Gibson, Meredith S. Brown, Jack A. Kosmicki, John P. Busanovich, Hope Wei, Laura M. Urbanski, Naomi Curimjee, Ashton C. Berger, Galen F. Gao, Andrew D. Cherniack, Sirano Dhe-Paganon, Brenton R. Paolella, Rameen Beroukhim
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
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Acceso en línea:https://doaj.org/article/86a1e531ffce47339d04b2ee5dc0b8e0
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https://doaj.org/article/86a1e531ffce47339d04b2ee5dc0b8e0

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