Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities

In tumors, hundreds of genes can undergo loss of heterozygosity (LOH). Here, the authors investigate the potential for this LOH as a class of non-driver cancer vulnerabilities.

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Autores principales:	Caitlin A. Nichols, William J. Gibson, Meredith S. Brown, Jack A. Kosmicki, John P. Busanovich, Hope Wei, Laura M. Urbanski, Naomi Curimjee, Ashton C. Berger, Galen F. Gao, Andrew D. Cherniack, Sirano Dhe-Paganon, Brenton R. Paolella, Rameen Beroukhim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/86a1e531ffce47339d04b2ee5dc0b8e0
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spelling	oai:doaj.org-article:86a1e531ffce47339d04b2ee5dc0b8e02021-12-02T15:45:19ZLoss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities10.1038/s41467-020-16399-y2041-1723https://doaj.org/article/86a1e531ffce47339d04b2ee5dc0b8e02020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16399-yhttps://doaj.org/toc/2041-1723In tumors, hundreds of genes can undergo loss of heterozygosity (LOH). Here, the authors investigate the potential for this LOH as a class of non-driver cancer vulnerabilities.Caitlin A. NicholsWilliam J. GibsonMeredith S. BrownJack A. KosmickiJohn P. BusanovichHope WeiLaura M. UrbanskiNaomi CurimjeeAshton C. BergerGalen F. GaoAndrew D. CherniackSirano Dhe-PaganonBrenton R. PaolellaRameen BeroukhimNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Caitlin A. Nichols William J. Gibson Meredith S. Brown Jack A. Kosmicki John P. Busanovich Hope Wei Laura M. Urbanski Naomi Curimjee Ashton C. Berger Galen F. Gao Andrew D. Cherniack Sirano Dhe-Paganon Brenton R. Paolella Rameen Beroukhim Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities
description	In tumors, hundreds of genes can undergo loss of heterozygosity (LOH). Here, the authors investigate the potential for this LOH as a class of non-driver cancer vulnerabilities.
format	article
author	Caitlin A. Nichols William J. Gibson Meredith S. Brown Jack A. Kosmicki John P. Busanovich Hope Wei Laura M. Urbanski Naomi Curimjee Ashton C. Berger Galen F. Gao Andrew D. Cherniack Sirano Dhe-Paganon Brenton R. Paolella Rameen Beroukhim
author_facet	Caitlin A. Nichols William J. Gibson Meredith S. Brown Jack A. Kosmicki John P. Busanovich Hope Wei Laura M. Urbanski Naomi Curimjee Ashton C. Berger Galen F. Gao Andrew D. Cherniack Sirano Dhe-Paganon Brenton R. Paolella Rameen Beroukhim
author_sort	Caitlin A. Nichols
title	Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities
title_short	Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities
title_full	Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities
title_fullStr	Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities
title_full_unstemmed	Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities
title_sort	loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/86a1e531ffce47339d04b2ee5dc0b8e0
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Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities

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