Caspase-8 mediates inflammation and disease in rodent malaria

Caspase-8 mediates inflammation and disease in rodent malaria

Inflammasome activation plays a role in malaria pathogenesis, but details aren’t well understood. Here, the authors show that caspase-8 is a central mediator of systemic inflammation in rodent malaria and that monocytes from malaria patients express active caspases-1, -4 and -8.

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Détails bibliographiques
Auteurs principaux: Larissa M. N. Pereira, Patrícia A. Assis, Natalia M. de Araújo, Danielle F. Durso, Caroline Junqueira, Marco Antônio Ataíde, Dhelio B. Pereira, Egil Lien, Katherine A. Fitzgerald, Dario S. Zamboni, Douglas T. Golenbock, Ricardo T. Gazzinelli
Format: article
Langue:EN
Publié: Nature Portfolio 2020
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/86a724147e8a447f9b51209768df08e2
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Internet

https://doaj.org/article/86a724147e8a447f9b51209768df08e2

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