Caspase-8 mediates inflammation and disease in rodent malaria

Inflammasome activation plays a role in malaria pathogenesis, but details aren’t well understood. Here, the authors show that caspase-8 is a central mediator of systemic inflammation in rodent malaria and that monocytes from malaria patients express active caspases-1, -4 and -8.

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Detalles Bibliográficos
Autores principales:	Larissa M. N. Pereira, Patrícia A. Assis, Natalia M. de Araújo, Danielle F. Durso, Caroline Junqueira, Marco Antônio Ataíde, Dhelio B. Pereira, Egil Lien, Katherine A. Fitzgerald, Dario S. Zamboni, Douglas T. Golenbock, Ricardo T. Gazzinelli
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/86a724147e8a447f9b51209768df08e2
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spelling	oai:doaj.org-article:86a724147e8a447f9b51209768df08e22021-12-02T15:16:06ZCaspase-8 mediates inflammation and disease in rodent malaria10.1038/s41467-020-18295-x2041-1723https://doaj.org/article/86a724147e8a447f9b51209768df08e22020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18295-xhttps://doaj.org/toc/2041-1723Inflammasome activation plays a role in malaria pathogenesis, but details aren’t well understood. Here, the authors show that caspase-8 is a central mediator of systemic inflammation in rodent malaria and that monocytes from malaria patients express active caspases-1, -4 and -8.Larissa M. N. PereiraPatrícia A. AssisNatalia M. de AraújoDanielle F. DursoCaroline JunqueiraMarco Antônio AtaídeDhelio B. PereiraEgil LienKatherine A. FitzgeraldDario S. ZamboniDouglas T. GolenbockRicardo T. GazzinelliNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Larissa M. N. Pereira Patrícia A. Assis Natalia M. de Araújo Danielle F. Durso Caroline Junqueira Marco Antônio Ataíde Dhelio B. Pereira Egil Lien Katherine A. Fitzgerald Dario S. Zamboni Douglas T. Golenbock Ricardo T. Gazzinelli Caspase-8 mediates inflammation and disease in rodent malaria
description	Inflammasome activation plays a role in malaria pathogenesis, but details aren’t well understood. Here, the authors show that caspase-8 is a central mediator of systemic inflammation in rodent malaria and that monocytes from malaria patients express active caspases-1, -4 and -8.
format	article
author	Larissa M. N. Pereira Patrícia A. Assis Natalia M. de Araújo Danielle F. Durso Caroline Junqueira Marco Antônio Ataíde Dhelio B. Pereira Egil Lien Katherine A. Fitzgerald Dario S. Zamboni Douglas T. Golenbock Ricardo T. Gazzinelli
author_facet	Larissa M. N. Pereira Patrícia A. Assis Natalia M. de Araújo Danielle F. Durso Caroline Junqueira Marco Antônio Ataíde Dhelio B. Pereira Egil Lien Katherine A. Fitzgerald Dario S. Zamboni Douglas T. Golenbock Ricardo T. Gazzinelli
author_sort	Larissa M. N. Pereira
title	Caspase-8 mediates inflammation and disease in rodent malaria
title_short	Caspase-8 mediates inflammation and disease in rodent malaria
title_full	Caspase-8 mediates inflammation and disease in rodent malaria
title_fullStr	Caspase-8 mediates inflammation and disease in rodent malaria
title_full_unstemmed	Caspase-8 mediates inflammation and disease in rodent malaria
title_sort	caspase-8 mediates inflammation and disease in rodent malaria
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/86a724147e8a447f9b51209768df08e2
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Caspase-8 mediates inflammation and disease in rodent malaria

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