HDAC2 targeting stabilizes the CoREST complex in renal tubular cells and protects against renal ischemia/reperfusion injury

HDAC2 targeting stabilizes the CoREST complex in renal tubular cells and protects against renal ischemia/reperfusion injury

Abstract Histone/protein deacetylases (HDAC) 1 and 2 are typically viewed as structurally and functionally similar enzymes present within various co-regulatory complexes. We tested differential effects of these isoforms in renal ischemia reperfusion injury (IRI) using inducible knockout mice and fou...

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Auteurs principaux: David D. Aufhauser, Paul Hernandez, Seth J. Concors, Ciaran O’Brien, Zhonglin Wang, Douglas R. Murken, Arabinda Samanta, Ulf H. Beier, Lauren Krumeich, Tricia R. Bhatti, Yanfeng Wang, Guanghui Ge, Liqing Wang, Shayan Cheraghlou, Florence F. Wagner, Edward B. Holson, Jay H. Kalin, Philip A. Cole, Wayne W. Hancock, Matthew H. Levine
Format: article
Langue:EN
Publié: Nature Portfolio 2021
Sujets:
Medicine
R
Science
Q
Accès en ligne:https://doaj.org/article/86bec5fc8fee49dbbb68530f910709b1
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https://doaj.org/article/86bec5fc8fee49dbbb68530f910709b1

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