Anti-Aging Activity of Xylocarpus Granatum Phytoextracts and Xyloccensins K Compound

Cellular aging is promoted by the deleterious effect of free radicals. This can be lowered by antioxidant treatments. Xylocarpus granatum and its compound, Xyloccensins K have been reported to have antioxidant activity but there have been no reports of antioxidant and anti-aging activities at the ce...

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Autores principales: Syarif Maulana Yusuf, Rika Indri Astuti, Irmanida Batubara, Warinthorn Chavasiri
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Publicado: Universitas Gadjah Mada 2021
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spelling oai:doaj.org-article:86cb213f89df45cdb7aaa05d23697f952021-11-15T06:08:46ZAnti-Aging Activity of Xylocarpus Granatum Phytoextracts and Xyloccensins K Compound2338-94272338-948610.22146/ijp.1430https://doaj.org/article/86cb213f89df45cdb7aaa05d23697f952021-08-01T00:00:00Zhttps://jurnal.ugm.ac.id/v3/IJP/article/view/1430https://doaj.org/toc/2338-9427https://doaj.org/toc/2338-9486Cellular aging is promoted by the deleterious effect of free radicals. This can be lowered by antioxidant treatments. Xylocarpus granatum and its compound, Xyloccensins K have been reported to have antioxidant activity but there have been no reports of antioxidant and anti-aging activities at the cellular level. Thus, the aim of this study to investigate the antioxidant and anti-aging properties of X. granatum-derived extract and Xyloccensins K at a cellular level in yeast Schizosaccharomyces pombe. Four vegetative and three generative parts of X. granatum organs including root, stem, leaf, twig, seed, flesh of fruit, and peel of fruit were extracted using 70% ethanol by the maceration method. Whereas, Xyloccensins K was obtained from seed of X. granatum.  The samples tested, other than peel of fruit, prolonged cell longevity in lower concentration as compared to that without phytoextracts treatment. Also, our data indicate that all samples could promote oxidative stress tolerance phenotype, as yeast was capable of dealing with H2O2-induced oxidative stress treatment at 1, 2, and 3 mM H2O2 with the best phenotypes by the administration of twig extracts. Most of the phytoextracts showed an increase in mitochondrial activity, except that of seed extract. The result showed the administration of Xyloccensins K compound did not increase the expression of transcriptional factors of oxidative stress response gene cluster, sty1 and pap1. We suggest that the Xyloccensins K compound acts as direct Reactive Oxygen Species (ROS) scavenger. Thus further study in elucidating the phenomenon of longevity-induced X. granatum extract is required.Syarif Maulana YusufRika Indri AstutiIrmanida BatubaraWarinthorn ChavasiriUniversitas Gadjah Madaarticleantioxidantlongevityreactive oxygen speciesPharmacy and materia medicaRS1-441ENIndonesian Journal of Pharmacy, Pp 365-375 (2021)
institution DOAJ
collection DOAJ
language EN
topic antioxidant
longevity
reactive oxygen species
Pharmacy and materia medica
RS1-441
spellingShingle antioxidant
longevity
reactive oxygen species
Pharmacy and materia medica
RS1-441
Syarif Maulana Yusuf
Rika Indri Astuti
Irmanida Batubara
Warinthorn Chavasiri
Anti-Aging Activity of Xylocarpus Granatum Phytoextracts and Xyloccensins K Compound
description Cellular aging is promoted by the deleterious effect of free radicals. This can be lowered by antioxidant treatments. Xylocarpus granatum and its compound, Xyloccensins K have been reported to have antioxidant activity but there have been no reports of antioxidant and anti-aging activities at the cellular level. Thus, the aim of this study to investigate the antioxidant and anti-aging properties of X. granatum-derived extract and Xyloccensins K at a cellular level in yeast Schizosaccharomyces pombe. Four vegetative and three generative parts of X. granatum organs including root, stem, leaf, twig, seed, flesh of fruit, and peel of fruit were extracted using 70% ethanol by the maceration method. Whereas, Xyloccensins K was obtained from seed of X. granatum.  The samples tested, other than peel of fruit, prolonged cell longevity in lower concentration as compared to that without phytoextracts treatment. Also, our data indicate that all samples could promote oxidative stress tolerance phenotype, as yeast was capable of dealing with H2O2-induced oxidative stress treatment at 1, 2, and 3 mM H2O2 with the best phenotypes by the administration of twig extracts. Most of the phytoextracts showed an increase in mitochondrial activity, except that of seed extract. The result showed the administration of Xyloccensins K compound did not increase the expression of transcriptional factors of oxidative stress response gene cluster, sty1 and pap1. We suggest that the Xyloccensins K compound acts as direct Reactive Oxygen Species (ROS) scavenger. Thus further study in elucidating the phenomenon of longevity-induced X. granatum extract is required.
format article
author Syarif Maulana Yusuf
Rika Indri Astuti
Irmanida Batubara
Warinthorn Chavasiri
author_facet Syarif Maulana Yusuf
Rika Indri Astuti
Irmanida Batubara
Warinthorn Chavasiri
author_sort Syarif Maulana Yusuf
title Anti-Aging Activity of Xylocarpus Granatum Phytoextracts and Xyloccensins K Compound
title_short Anti-Aging Activity of Xylocarpus Granatum Phytoextracts and Xyloccensins K Compound
title_full Anti-Aging Activity of Xylocarpus Granatum Phytoextracts and Xyloccensins K Compound
title_fullStr Anti-Aging Activity of Xylocarpus Granatum Phytoextracts and Xyloccensins K Compound
title_full_unstemmed Anti-Aging Activity of Xylocarpus Granatum Phytoextracts and Xyloccensins K Compound
title_sort anti-aging activity of xylocarpus granatum phytoextracts and xyloccensins k compound
publisher Universitas Gadjah Mada
publishDate 2021
url https://doaj.org/article/86cb213f89df45cdb7aaa05d23697f95
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