Peritoneal tissue-resident macrophages are metabolically poised to engage microbes using tissue-niche fuels

Tissue-resident marcophages have both generic and tissue-specific functions, but how the latter functions are imbued is still unclear. Here the authors show that peritoneal macrophages express a specialised genetic programme to utilise the locally enriched glutamate for a metabolic setting that faci...

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Autores principales:	Luke C. Davies, Christopher M. Rice, Erika M. Palmieri, Philip R. Taylor, Douglas B. Kuhns, Daniel W. McVicar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/86ef4b42bcbf4bb9ae3a3b8087faf78b
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spelling	oai:doaj.org-article:86ef4b42bcbf4bb9ae3a3b8087faf78b2021-12-02T14:42:16ZPeritoneal tissue-resident macrophages are metabolically poised to engage microbes using tissue-niche fuels10.1038/s41467-017-02092-02041-1723https://doaj.org/article/86ef4b42bcbf4bb9ae3a3b8087faf78b2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02092-0https://doaj.org/toc/2041-1723Tissue-resident marcophages have both generic and tissue-specific functions, but how the latter functions are imbued is still unclear. Here the authors show that peritoneal macrophages express a specialised genetic programme to utilise the locally enriched glutamate for a metabolic setting that facilitates protective in situ immunity.Luke C. DaviesChristopher M. RiceErika M. PalmieriPhilip R. TaylorDouglas B. KuhnsDaniel W. McVicarNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Luke C. Davies Christopher M. Rice Erika M. Palmieri Philip R. Taylor Douglas B. Kuhns Daniel W. McVicar Peritoneal tissue-resident macrophages are metabolically poised to engage microbes using tissue-niche fuels
description	Tissue-resident marcophages have both generic and tissue-specific functions, but how the latter functions are imbued is still unclear. Here the authors show that peritoneal macrophages express a specialised genetic programme to utilise the locally enriched glutamate for a metabolic setting that facilitates protective in situ immunity.
format	article
author	Luke C. Davies Christopher M. Rice Erika M. Palmieri Philip R. Taylor Douglas B. Kuhns Daniel W. McVicar
author_facet	Luke C. Davies Christopher M. Rice Erika M. Palmieri Philip R. Taylor Douglas B. Kuhns Daniel W. McVicar
author_sort	Luke C. Davies
title	Peritoneal tissue-resident macrophages are metabolically poised to engage microbes using tissue-niche fuels
title_short	Peritoneal tissue-resident macrophages are metabolically poised to engage microbes using tissue-niche fuels
title_full	Peritoneal tissue-resident macrophages are metabolically poised to engage microbes using tissue-niche fuels
title_fullStr	Peritoneal tissue-resident macrophages are metabolically poised to engage microbes using tissue-niche fuels
title_full_unstemmed	Peritoneal tissue-resident macrophages are metabolically poised to engage microbes using tissue-niche fuels
title_sort	peritoneal tissue-resident macrophages are metabolically poised to engage microbes using tissue-niche fuels
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/86ef4b42bcbf4bb9ae3a3b8087faf78b
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Peritoneal tissue-resident macrophages are metabolically poised to engage microbes using tissue-niche fuels

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