Mechanisms of drug interactions between translation-inhibiting antibiotics
Antibiotics targeting protein translation interact in hard-to-predict ways. Here, Kavčič et al. interpret these interactions in terms of translation bottlenecks, the kinetics of drug uptake and target binding, bacterial growth laws, and a model of queued traffic progression.
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Nature Portfolio
2020
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oai:doaj.org-article:86f5aab737f64934aa1e07c0896df11f2021-12-02T15:07:56ZMechanisms of drug interactions between translation-inhibiting antibiotics10.1038/s41467-020-17734-z2041-1723https://doaj.org/article/86f5aab737f64934aa1e07c0896df11f2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17734-zhttps://doaj.org/toc/2041-1723Antibiotics targeting protein translation interact in hard-to-predict ways. Here, Kavčič et al. interpret these interactions in terms of translation bottlenecks, the kinetics of drug uptake and target binding, bacterial growth laws, and a model of queued traffic progression.Bor KavčičGašper TkačikTobias BollenbachNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020) |
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Science Q Bor Kavčič Gašper Tkačik Tobias Bollenbach Mechanisms of drug interactions between translation-inhibiting antibiotics |
description |
Antibiotics targeting protein translation interact in hard-to-predict ways. Here, Kavčič et al. interpret these interactions in terms of translation bottlenecks, the kinetics of drug uptake and target binding, bacterial growth laws, and a model of queued traffic progression. |
format |
article |
author |
Bor Kavčič Gašper Tkačik Tobias Bollenbach |
author_facet |
Bor Kavčič Gašper Tkačik Tobias Bollenbach |
author_sort |
Bor Kavčič |
title |
Mechanisms of drug interactions between translation-inhibiting antibiotics |
title_short |
Mechanisms of drug interactions between translation-inhibiting antibiotics |
title_full |
Mechanisms of drug interactions between translation-inhibiting antibiotics |
title_fullStr |
Mechanisms of drug interactions between translation-inhibiting antibiotics |
title_full_unstemmed |
Mechanisms of drug interactions between translation-inhibiting antibiotics |
title_sort |
mechanisms of drug interactions between translation-inhibiting antibiotics |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/86f5aab737f64934aa1e07c0896df11f |
work_keys_str_mv |
AT borkavcic mechanismsofdruginteractionsbetweentranslationinhibitingantibiotics AT gaspertkacik mechanismsofdruginteractionsbetweentranslationinhibitingantibiotics AT tobiasbollenbach mechanismsofdruginteractionsbetweentranslationinhibitingantibiotics |
_version_ |
1718388328881979392 |