Mechanisms of drug interactions between translation-inhibiting antibiotics

Antibiotics targeting protein translation interact in hard-to-predict ways. Here, Kavčič et al. interpret these interactions in terms of translation bottlenecks, the kinetics of drug uptake and target binding, bacterial growth laws, and a model of queued traffic progression.

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Autores principales: Bor Kavčič, Gašper Tkačik, Tobias Bollenbach
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/86f5aab737f64934aa1e07c0896df11f
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spelling oai:doaj.org-article:86f5aab737f64934aa1e07c0896df11f2021-12-02T15:07:56ZMechanisms of drug interactions between translation-inhibiting antibiotics10.1038/s41467-020-17734-z2041-1723https://doaj.org/article/86f5aab737f64934aa1e07c0896df11f2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17734-zhttps://doaj.org/toc/2041-1723Antibiotics targeting protein translation interact in hard-to-predict ways. Here, Kavčič et al. interpret these interactions in terms of translation bottlenecks, the kinetics of drug uptake and target binding, bacterial growth laws, and a model of queued traffic progression.Bor KavčičGašper TkačikTobias BollenbachNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Bor Kavčič
Gašper Tkačik
Tobias Bollenbach
Mechanisms of drug interactions between translation-inhibiting antibiotics
description Antibiotics targeting protein translation interact in hard-to-predict ways. Here, Kavčič et al. interpret these interactions in terms of translation bottlenecks, the kinetics of drug uptake and target binding, bacterial growth laws, and a model of queued traffic progression.
format article
author Bor Kavčič
Gašper Tkačik
Tobias Bollenbach
author_facet Bor Kavčič
Gašper Tkačik
Tobias Bollenbach
author_sort Bor Kavčič
title Mechanisms of drug interactions between translation-inhibiting antibiotics
title_short Mechanisms of drug interactions between translation-inhibiting antibiotics
title_full Mechanisms of drug interactions between translation-inhibiting antibiotics
title_fullStr Mechanisms of drug interactions between translation-inhibiting antibiotics
title_full_unstemmed Mechanisms of drug interactions between translation-inhibiting antibiotics
title_sort mechanisms of drug interactions between translation-inhibiting antibiotics
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/86f5aab737f64934aa1e07c0896df11f
work_keys_str_mv AT borkavcic mechanismsofdruginteractionsbetweentranslationinhibitingantibiotics
AT gaspertkacik mechanismsofdruginteractionsbetweentranslationinhibitingantibiotics
AT tobiasbollenbach mechanismsofdruginteractionsbetweentranslationinhibitingantibiotics
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