Mechanisms of drug interactions between translation-inhibiting antibiotics

Antibiotics targeting protein translation interact in hard-to-predict ways. Here, Kavčič et al. interpret these interactions in terms of translation bottlenecks, the kinetics of drug uptake and target binding, bacterial growth laws, and a model of queued traffic progression.

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Autores principales:	Bor Kavčič, Gašper Tkačik, Tobias Bollenbach
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/86f5aab737f64934aa1e07c0896df11f
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spelling	oai:doaj.org-article:86f5aab737f64934aa1e07c0896df11f2021-12-02T15:07:56ZMechanisms of drug interactions between translation-inhibiting antibiotics10.1038/s41467-020-17734-z2041-1723https://doaj.org/article/86f5aab737f64934aa1e07c0896df11f2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17734-zhttps://doaj.org/toc/2041-1723Antibiotics targeting protein translation interact in hard-to-predict ways. Here, Kavčič et al. interpret these interactions in terms of translation bottlenecks, the kinetics of drug uptake and target binding, bacterial growth laws, and a model of queued traffic progression.Bor KavčičGašper TkačikTobias BollenbachNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bor Kavčič Gašper Tkačik Tobias Bollenbach Mechanisms of drug interactions between translation-inhibiting antibiotics
description	Antibiotics targeting protein translation interact in hard-to-predict ways. Here, Kavčič et al. interpret these interactions in terms of translation bottlenecks, the kinetics of drug uptake and target binding, bacterial growth laws, and a model of queued traffic progression.
format	article
author	Bor Kavčič Gašper Tkačik Tobias Bollenbach
author_facet	Bor Kavčič Gašper Tkačik Tobias Bollenbach
author_sort	Bor Kavčič
title	Mechanisms of drug interactions between translation-inhibiting antibiotics
title_short	Mechanisms of drug interactions between translation-inhibiting antibiotics
title_full	Mechanisms of drug interactions between translation-inhibiting antibiotics
title_fullStr	Mechanisms of drug interactions between translation-inhibiting antibiotics
title_full_unstemmed	Mechanisms of drug interactions between translation-inhibiting antibiotics
title_sort	mechanisms of drug interactions between translation-inhibiting antibiotics
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/86f5aab737f64934aa1e07c0896df11f
work_keys_str_mv	AT borkavcic mechanismsofdruginteractionsbetweentranslationinhibitingantibiotics AT gaspertkacik mechanismsofdruginteractionsbetweentranslationinhibitingantibiotics AT tobiasbollenbach mechanismsofdruginteractionsbetweentranslationinhibitingantibiotics
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Mechanisms of drug interactions between translation-inhibiting antibiotics

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