MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage

Homologous recombination (HR) is an essential DNA repair pathway for genomic stability. Here the authors show that C17orf53/MCM8IP, an OB-fold containing protein, promotes HR through direct binding and activation of the MCM8-9 helicase complex.

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Autores principales:	Jen-Wei Huang, Ananya Acharya, Angelo Taglialatela, Tarun S. Nambiar, Raquel Cuella-Martin, Giuseppe Leuzzi, Samuel B. Hayward, Sarah A. Joseph, Gregory J. Brunette, Roopesh Anand, Rajesh K. Soni, Nathan L. Clark, Kara A. Bernstein, Petr Cejka, Alberto Ciccia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/86fa91a9e36c4bd1bfde918a8bfb93ee
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spelling	oai:doaj.org-article:86fa91a9e36c4bd1bfde918a8bfb93ee2021-12-02T17:47:59ZMCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage10.1038/s41467-020-16718-32041-1723https://doaj.org/article/86fa91a9e36c4bd1bfde918a8bfb93ee2020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16718-3https://doaj.org/toc/2041-1723Homologous recombination (HR) is an essential DNA repair pathway for genomic stability. Here the authors show that C17orf53/MCM8IP, an OB-fold containing protein, promotes HR through direct binding and activation of the MCM8-9 helicase complex.Jen-Wei HuangAnanya AcharyaAngelo TaglialatelaTarun S. NambiarRaquel Cuella-MartinGiuseppe LeuzziSamuel B. HaywardSarah A. JosephGregory J. BrunetteRoopesh AnandRajesh K. SoniNathan L. ClarkKara A. BernsteinPetr CejkaAlberto CicciaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jen-Wei Huang Ananya Acharya Angelo Taglialatela Tarun S. Nambiar Raquel Cuella-Martin Giuseppe Leuzzi Samuel B. Hayward Sarah A. Joseph Gregory J. Brunette Roopesh Anand Rajesh K. Soni Nathan L. Clark Kara A. Bernstein Petr Cejka Alberto Ciccia MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage
description	Homologous recombination (HR) is an essential DNA repair pathway for genomic stability. Here the authors show that C17orf53/MCM8IP, an OB-fold containing protein, promotes HR through direct binding and activation of the MCM8-9 helicase complex.
format	article
author	Jen-Wei Huang Ananya Acharya Angelo Taglialatela Tarun S. Nambiar Raquel Cuella-Martin Giuseppe Leuzzi Samuel B. Hayward Sarah A. Joseph Gregory J. Brunette Roopesh Anand Rajesh K. Soni Nathan L. Clark Kara A. Bernstein Petr Cejka Alberto Ciccia
author_facet	Jen-Wei Huang Ananya Acharya Angelo Taglialatela Tarun S. Nambiar Raquel Cuella-Martin Giuseppe Leuzzi Samuel B. Hayward Sarah A. Joseph Gregory J. Brunette Roopesh Anand Rajesh K. Soni Nathan L. Clark Kara A. Bernstein Petr Cejka Alberto Ciccia
author_sort	Jen-Wei Huang
title	MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage
title_short	MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage
title_full	MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage
title_fullStr	MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage
title_full_unstemmed	MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage
title_sort	mcm8ip activates the mcm8-9 helicase to promote dna synthesis and homologous recombination upon dna damage
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/86fa91a9e36c4bd1bfde918a8bfb93ee
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MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage

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