Pan-ROCK and ROCK2 Inhibitors Affect Dexamethasone-Treated 2D- and 3D-Cultured Human Trabecular Meshwork (HTM) Cells in Opposite Manners

Pan-ROCK and ROCK2 Inhibitors Affect Dexamethasone-Treated 2D- and 3D-Cultured Human Trabecular Meshwork (HTM) Cells in Opposite Manners

Effects of a pan-ROCK-inhibitor, ripasudil (Rip), and a ROCK2 inhibitor, KD025 on dexamethasone (DEX)-treated human trabecular meshwork (HTM) cells as a model of steroid-induced glaucoma were investigated. In the presence of Rip or KD025, DEX-treated HTM cells were subjected to permeability analysis...

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Autores principales: Megumi Watanabe, Yosuke Ida, Masato Furuhashi, Yuri Tsugeno, Fumihito Hikage, Hiroshi Ohguro
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
3D spheroid cultures
human trabecular meshwork (HTM)
Rho-associated coiled-coil containing protein kinase (ROCK)
ripasudil
KD025
dexamethasone
Organic chemistry
QD241-441
Acceso en línea:https://doaj.org/article/87169559e7f3417f91f53c735e7bf2e0
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https://doaj.org/article/87169559e7f3417f91f53c735e7bf2e0

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