ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor.
Pseudokinases lack essential residues for kinase activity, yet are emerging as important regulators of signal transduction networks. The pseudokinase STRAD activates the LKB1 tumour suppressor by forming a heterotrimeric complex with LKB1 and the scaffolding protein MO25. Here, we describe the struc...
Enregistré dans:
Auteurs principaux: | , , , , , , , |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Public Library of Science (PLoS)
2009
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/87243bf4692f4c489aefd29c82f67659 |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|