Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells

Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells

PPARγ promotes free fatty acid uptake and also has a role in T cell regulation. Here the authors show that mTORC1-PPARγ signalling is needed for fatty acid uptake by activated CD4+T cells and for clonal expansion of these cells.

Guardado en:
Detalles Bibliográficos
Autores principales: Mulki Angela, Yusuke Endo, Hikari K. Asou, Takeshi Yamamoto, Damon J. Tumes, Hirotake Tokuyama, Koutaro Yokote, Toshinori Nakayama
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/872f8a9911d2463e957bee8d463e00e8
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:872f8a9911d2463e957bee8d463e00e8
record_format dspace
spelling oai:doaj.org-article:872f8a9911d2463e957bee8d463e00e82021-12-02T17:33:09ZFatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells10.1038/ncomms136832041-1723https://doaj.org/article/872f8a9911d2463e957bee8d463e00e82016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13683https://doaj.org/toc/2041-1723PPARγ promotes free fatty acid uptake and also has a role in T cell regulation. Here the authors show that mTORC1-PPARγ signalling is needed for fatty acid uptake by activated CD4+T cells and for clonal expansion of these cells.Mulki AngelaYusuke EndoHikari K. AsouTakeshi YamamotoDamon J. TumesHirotake TokuyamaKoutaro YokoteToshinori NakayamaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Mulki Angela
Yusuke Endo
Hikari K. Asou
Takeshi Yamamoto
Damon J. Tumes
Hirotake Tokuyama
Koutaro Yokote
Toshinori Nakayama
Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells
description PPARγ promotes free fatty acid uptake and also has a role in T cell regulation. Here the authors show that mTORC1-PPARγ signalling is needed for fatty acid uptake by activated CD4+T cells and for clonal expansion of these cells.
format article
author Mulki Angela
Yusuke Endo
Hikari K. Asou
Takeshi Yamamoto
Damon J. Tumes
Hirotake Tokuyama
Koutaro Yokote
Toshinori Nakayama
author_facet Mulki Angela
Yusuke Endo
Hikari K. Asou
Takeshi Yamamoto
Damon J. Tumes
Hirotake Tokuyama
Koutaro Yokote
Toshinori Nakayama
author_sort Mulki Angela
title Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells
title_short Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells
title_full Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells
title_fullStr Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells
title_full_unstemmed Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells
title_sort fatty acid metabolic reprogramming via mtor-mediated inductions of pparγ directs early activation of t cells
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/872f8a9911d2463e957bee8d463e00e8
work_keys_str_mv AT mulkiangela fattyacidmetabolicreprogrammingviamtormediatedinductionsofppargdirectsearlyactivationoftcells
AT yusukeendo fattyacidmetabolicreprogrammingviamtormediatedinductionsofppargdirectsearlyactivationoftcells
AT hikarikasou fattyacidmetabolicreprogrammingviamtormediatedinductionsofppargdirectsearlyactivationoftcells
AT takeshiyamamoto fattyacidmetabolicreprogrammingviamtormediatedinductionsofppargdirectsearlyactivationoftcells
AT damonjtumes fattyacidmetabolicreprogrammingviamtormediatedinductionsofppargdirectsearlyactivationoftcells
AT hirotaketokuyama fattyacidmetabolicreprogrammingviamtormediatedinductionsofppargdirectsearlyactivationoftcells
AT koutaroyokote fattyacidmetabolicreprogrammingviamtormediatedinductionsofppargdirectsearlyactivationoftcells
AT toshinorinakayama fattyacidmetabolicreprogrammingviamtormediatedinductionsofppargdirectsearlyactivationoftcells
_version_ 1718380071826227200

Ejemplares similares