How single mutations affect viral escape from broad and narrow antibodies to H1 influenza hemagglutinin

Influenza A virus can escape antibodies, but it is unclear how the ease of escape depends on the epitope targeted by an antibody. Here, the authors show that neutralization breadth is an imperfect indicator of the ease of viral escape by single mutations, and that antibodies targeting the stalk of h...

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Autores principales:	Michael B. Doud, Juhye M. Lee, Jesse D. Bloom
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/876257bdebd1481d98820158c8928e1b
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spelling	oai:doaj.org-article:876257bdebd1481d98820158c8928e1b2021-12-02T14:41:05ZHow single mutations affect viral escape from broad and narrow antibodies to H1 influenza hemagglutinin10.1038/s41467-018-03665-32041-1723https://doaj.org/article/876257bdebd1481d98820158c8928e1b2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03665-3https://doaj.org/toc/2041-1723Influenza A virus can escape antibodies, but it is unclear how the ease of escape depends on the epitope targeted by an antibody. Here, the authors show that neutralization breadth is an imperfect indicator of the ease of viral escape by single mutations, and that antibodies targeting the stalk of hemagglutinin are harder to escape.Michael B. DoudJuhye M. LeeJesse D. BloomNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael B. Doud Juhye M. Lee Jesse D. Bloom How single mutations affect viral escape from broad and narrow antibodies to H1 influenza hemagglutinin
description	Influenza A virus can escape antibodies, but it is unclear how the ease of escape depends on the epitope targeted by an antibody. Here, the authors show that neutralization breadth is an imperfect indicator of the ease of viral escape by single mutations, and that antibodies targeting the stalk of hemagglutinin are harder to escape.
format	article
author	Michael B. Doud Juhye M. Lee Jesse D. Bloom
author_facet	Michael B. Doud Juhye M. Lee Jesse D. Bloom
author_sort	Michael B. Doud
title	How single mutations affect viral escape from broad and narrow antibodies to H1 influenza hemagglutinin
title_short	How single mutations affect viral escape from broad and narrow antibodies to H1 influenza hemagglutinin
title_full	How single mutations affect viral escape from broad and narrow antibodies to H1 influenza hemagglutinin
title_fullStr	How single mutations affect viral escape from broad and narrow antibodies to H1 influenza hemagglutinin
title_full_unstemmed	How single mutations affect viral escape from broad and narrow antibodies to H1 influenza hemagglutinin
title_sort	how single mutations affect viral escape from broad and narrow antibodies to h1 influenza hemagglutinin
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/876257bdebd1481d98820158c8928e1b
work_keys_str_mv	AT michaelbdoud howsinglemutationsaffectviralescapefrombroadandnarrowantibodiestoh1influenzahemagglutinin AT juhyemlee howsinglemutationsaffectviralescapefrombroadandnarrowantibodiestoh1influenzahemagglutinin AT jessedbloom howsinglemutationsaffectviralescapefrombroadandnarrowantibodiestoh1influenzahemagglutinin
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How single mutations affect viral escape from broad and narrow antibodies to H1 influenza hemagglutinin

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