How single mutations affect viral escape from broad and narrow antibodies to H1 influenza hemagglutinin

Influenza A virus can escape antibodies, but it is unclear how the ease of escape depends on the epitope targeted by an antibody. Here, the authors show that neutralization breadth is an imperfect indicator of the ease of viral escape by single mutations, and that antibodies targeting the stalk of h...

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Autores principales: Michael B. Doud, Juhye M. Lee, Jesse D. Bloom
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/876257bdebd1481d98820158c8928e1b
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