PEP-19 modulates calcium binding to calmodulin by electrostatic steering

The protein PEP-19 increases the rates of calcium binding to calmodulin. Here, the authors report the structure of PEP-19 bound to the C-terminal domain of calmodulin, and are able to propose a mechanism for the observed increased calcium association rate.

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Detalles Bibliográficos
Autores principales:	Xu Wang, John A. Putkey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/87656c6f7cf54997bf12ecd08c72d76c
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spelling	oai:doaj.org-article:87656c6f7cf54997bf12ecd08c72d76c2021-12-02T17:31:20ZPEP-19 modulates calcium binding to calmodulin by electrostatic steering10.1038/ncomms135832041-1723https://doaj.org/article/87656c6f7cf54997bf12ecd08c72d76c2016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13583https://doaj.org/toc/2041-1723The protein PEP-19 increases the rates of calcium binding to calmodulin. Here, the authors report the structure of PEP-19 bound to the C-terminal domain of calmodulin, and are able to propose a mechanism for the observed increased calcium association rate.Xu WangJohn A. PutkeyNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xu Wang John A. Putkey PEP-19 modulates calcium binding to calmodulin by electrostatic steering
description	The protein PEP-19 increases the rates of calcium binding to calmodulin. Here, the authors report the structure of PEP-19 bound to the C-terminal domain of calmodulin, and are able to propose a mechanism for the observed increased calcium association rate.
format	article
author	Xu Wang John A. Putkey
author_facet	Xu Wang John A. Putkey
author_sort	Xu Wang
title	PEP-19 modulates calcium binding to calmodulin by electrostatic steering
title_short	PEP-19 modulates calcium binding to calmodulin by electrostatic steering
title_full	PEP-19 modulates calcium binding to calmodulin by electrostatic steering
title_fullStr	PEP-19 modulates calcium binding to calmodulin by electrostatic steering
title_full_unstemmed	PEP-19 modulates calcium binding to calmodulin by electrostatic steering
title_sort	pep-19 modulates calcium binding to calmodulin by electrostatic steering
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/87656c6f7cf54997bf12ecd08c72d76c
work_keys_str_mv	AT xuwang pep19modulatescalciumbindingtocalmodulinbyelectrostaticsteering AT johnaputkey pep19modulatescalciumbindingtocalmodulinbyelectrostaticsteering
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PEP-19 modulates calcium binding to calmodulin by electrostatic steering

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