Analysis of Dissolution of Salicylamide from Carrageenan Based Hard-Shell Capsules: A Study of the Drug-Matrix Interaction

In drug release kinetics, the drug-matrix interaction is one of the important mechanisms to be dictated. Unfortunately, there is still minimum information discussing the effect of interaction between a drug and its matrix to the release profile of the drug. Therefore, there is an urgent need to cond...

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Main Authors:	Muhammad Al Rizqi Dharma Fauzi, Esti Hendradi, Pratiwi Pudjiastuti, Riyanto Teguh Widodo
Format:	article
Language:	EN
Published:	Department of Chemistry, Universitas Gadjah Mada 2020
Subjects:	polymer carrageenan drug release release kinetic dissolution Chemistry QD1-999
Online Access:	https://doaj.org/article/87754166cc6946c1bb1e2e1724d2d20f
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spelling	oai:doaj.org-article:87754166cc6946c1bb1e2e1724d2d20f2021-12-02T14:00:19ZAnalysis of Dissolution of Salicylamide from Carrageenan Based Hard-Shell Capsules: A Study of the Drug-Matrix Interaction1411-94202460-157810.22146/ijc.55047https://doaj.org/article/87754166cc6946c1bb1e2e1724d2d20f2020-11-01T00:00:00Zhttps://jurnal.ugm.ac.id/ijc/article/view/55047https://doaj.org/toc/1411-9420https://doaj.org/toc/2460-1578In drug release kinetics, the drug-matrix interaction is one of the important mechanisms to be dictated. Unfortunately, there is still minimum information discussing the effect of interaction between a drug and its matrix to the release profile of the drug. Therefore, there is an urgent need to conduct research related to the study of drug-matrix interaction. This paper reports the preparation of a drug delivery system (DDS) in the form of hard-shell capsules containing salicylamide (SCA) and analyses its drug-matrix interaction via dissolution test at different pH media and various release kinetics models. The matrix of hard-shell capsules was prepared from κ-carrageenan (CRG), crosslinked with maltodextrin (MD), and plasticized by sorbitol (SOR). The chemical properties of SCA were compared with paracetamol (PCT) using computational analysis to help to depict its drug-matrix interaction. The statistical analyses showed that SCA and PCT at pH 1.2, 4.5, and 6.8 had all different release profiles. Based on the goodness of fit evaluation, the diffusion mechanism of SCA at pH 1.2 and 4.5 could be best described by the Peppas-Sahlin model while the zeroth-order model fitted the dissolution profile at pH 6.8. In summary, it was proven that a different drug-matrix interaction produced a different dissolution profile.Muhammad Al Rizqi Dharma FauziEsti HendradiPratiwi PudjiastutiRiyanto Teguh WidodoDepartment of Chemistry, Universitas Gadjah Madaarticlepolymercarrageenandrug releaserelease kineticdissolutionChemistryQD1-999ENIndonesian Journal of Chemistry, Vol 21, Iss 1, Pp 148-156 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	polymer carrageenan drug release release kinetic dissolution Chemistry QD1-999
spellingShingle	polymer carrageenan drug release release kinetic dissolution Chemistry QD1-999 Muhammad Al Rizqi Dharma Fauzi Esti Hendradi Pratiwi Pudjiastuti Riyanto Teguh Widodo Analysis of Dissolution of Salicylamide from Carrageenan Based Hard-Shell Capsules: A Study of the Drug-Matrix Interaction
description	In drug release kinetics, the drug-matrix interaction is one of the important mechanisms to be dictated. Unfortunately, there is still minimum information discussing the effect of interaction between a drug and its matrix to the release profile of the drug. Therefore, there is an urgent need to conduct research related to the study of drug-matrix interaction. This paper reports the preparation of a drug delivery system (DDS) in the form of hard-shell capsules containing salicylamide (SCA) and analyses its drug-matrix interaction via dissolution test at different pH media and various release kinetics models. The matrix of hard-shell capsules was prepared from κ-carrageenan (CRG), crosslinked with maltodextrin (MD), and plasticized by sorbitol (SOR). The chemical properties of SCA were compared with paracetamol (PCT) using computational analysis to help to depict its drug-matrix interaction. The statistical analyses showed that SCA and PCT at pH 1.2, 4.5, and 6.8 had all different release profiles. Based on the goodness of fit evaluation, the diffusion mechanism of SCA at pH 1.2 and 4.5 could be best described by the Peppas-Sahlin model while the zeroth-order model fitted the dissolution profile at pH 6.8. In summary, it was proven that a different drug-matrix interaction produced a different dissolution profile.
format	article
author	Muhammad Al Rizqi Dharma Fauzi Esti Hendradi Pratiwi Pudjiastuti Riyanto Teguh Widodo
author_facet	Muhammad Al Rizqi Dharma Fauzi Esti Hendradi Pratiwi Pudjiastuti Riyanto Teguh Widodo
author_sort	Muhammad Al Rizqi Dharma Fauzi
title	Analysis of Dissolution of Salicylamide from Carrageenan Based Hard-Shell Capsules: A Study of the Drug-Matrix Interaction
title_short	Analysis of Dissolution of Salicylamide from Carrageenan Based Hard-Shell Capsules: A Study of the Drug-Matrix Interaction
title_full	Analysis of Dissolution of Salicylamide from Carrageenan Based Hard-Shell Capsules: A Study of the Drug-Matrix Interaction
title_fullStr	Analysis of Dissolution of Salicylamide from Carrageenan Based Hard-Shell Capsules: A Study of the Drug-Matrix Interaction
title_full_unstemmed	Analysis of Dissolution of Salicylamide from Carrageenan Based Hard-Shell Capsules: A Study of the Drug-Matrix Interaction
title_sort	analysis of dissolution of salicylamide from carrageenan based hard-shell capsules: a study of the drug-matrix interaction
publisher	Department of Chemistry, Universitas Gadjah Mada
publishDate	2020
url	https://doaj.org/article/87754166cc6946c1bb1e2e1724d2d20f
work_keys_str_mv	AT muhammadalrizqidharmafauzi analysisofdissolutionofsalicylamidefromcarrageenanbasedhardshellcapsulesastudyofthedrugmatrixinteraction AT estihendradi analysisofdissolutionofsalicylamidefromcarrageenanbasedhardshellcapsulesastudyofthedrugmatrixinteraction AT pratiwipudjiastuti analysisofdissolutionofsalicylamidefromcarrageenanbasedhardshellcapsulesastudyofthedrugmatrixinteraction AT riyantoteguhwidodo analysisofdissolutionofsalicylamidefromcarrageenanbasedhardshellcapsulesastudyofthedrugmatrixinteraction
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Analysis of Dissolution of Salicylamide from Carrageenan Based Hard-Shell Capsules: A Study of the Drug-Matrix Interaction

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