Challenges in identifying cancer genes by analysis of exome sequencing data

Next generation sequencing has been pivotal in identifying somatic mutations in cancer samples. In this study, the authors analyse whole exome sequencing data using a variety of bioinformatic methods to identify mutations in known cancer genes and find that many cancer genes are not detected by thes...

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Autores principales:	Matan Hofree, Hannah Carter, Jason F. Kreisberg, Sourav Bandyopadhyay, Paul S. Mischel, Stephen Friend, Trey Ideker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/87762e638f7841b283cf8f611ee7e94e
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id	oai:doaj.org-article:87762e638f7841b283cf8f611ee7e94e
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spelling	oai:doaj.org-article:87762e638f7841b283cf8f611ee7e94e2021-12-02T15:34:33ZChallenges in identifying cancer genes by analysis of exome sequencing data10.1038/ncomms120962041-1723https://doaj.org/article/87762e638f7841b283cf8f611ee7e94e2016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12096https://doaj.org/toc/2041-1723Next generation sequencing has been pivotal in identifying somatic mutations in cancer samples. In this study, the authors analyse whole exome sequencing data using a variety of bioinformatic methods to identify mutations in known cancer genes and find that many cancer genes are not detected by these methods.Matan HofreeHannah CarterJason F. KreisbergSourav BandyopadhyayPaul S. MischelStephen FriendTrey IdekerNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Matan Hofree Hannah Carter Jason F. Kreisberg Sourav Bandyopadhyay Paul S. Mischel Stephen Friend Trey Ideker Challenges in identifying cancer genes by analysis of exome sequencing data
description	Next generation sequencing has been pivotal in identifying somatic mutations in cancer samples. In this study, the authors analyse whole exome sequencing data using a variety of bioinformatic methods to identify mutations in known cancer genes and find that many cancer genes are not detected by these methods.
format	article
author	Matan Hofree Hannah Carter Jason F. Kreisberg Sourav Bandyopadhyay Paul S. Mischel Stephen Friend Trey Ideker
author_facet	Matan Hofree Hannah Carter Jason F. Kreisberg Sourav Bandyopadhyay Paul S. Mischel Stephen Friend Trey Ideker
author_sort	Matan Hofree
title	Challenges in identifying cancer genes by analysis of exome sequencing data
title_short	Challenges in identifying cancer genes by analysis of exome sequencing data
title_full	Challenges in identifying cancer genes by analysis of exome sequencing data
title_fullStr	Challenges in identifying cancer genes by analysis of exome sequencing data
title_full_unstemmed	Challenges in identifying cancer genes by analysis of exome sequencing data
title_sort	challenges in identifying cancer genes by analysis of exome sequencing data
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/87762e638f7841b283cf8f611ee7e94e
work_keys_str_mv	AT matanhofree challengesinidentifyingcancergenesbyanalysisofexomesequencingdata AT hannahcarter challengesinidentifyingcancergenesbyanalysisofexomesequencingdata AT jasonfkreisberg challengesinidentifyingcancergenesbyanalysisofexomesequencingdata AT souravbandyopadhyay challengesinidentifyingcancergenesbyanalysisofexomesequencingdata AT paulsmischel challengesinidentifyingcancergenesbyanalysisofexomesequencingdata AT stephenfriend challengesinidentifyingcancergenesbyanalysisofexomesequencingdata AT treyideker challengesinidentifyingcancergenesbyanalysisofexomesequencingdata
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Challenges in identifying cancer genes by analysis of exome sequencing data

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