Pharmacological characterization of [³H]CHIBA-3007 binding to glycine transporter 1 in the rat brain.

Glycine transporter-1 (GlyT-1) in glial cells regulates extracellular levels of glycine, which acts as an obligatory co-agonist at the N-methyl-D-aspartate (NMDA) receptors in the brain. In the present study, we developed a novel radioligand, [³H]3-chloro-N-((S)-((R)-1-methylpiperidin-2-yl)(thiophen...

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Autores principales: Jichun Zhang, Jin Wu, Jun Toyohara, Yuko Fujita, Hongxian Chen, Kenji Hashimoto
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2011
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Acceso en línea:https://doaj.org/article/8781b0f9301b4f59b14d94f7f61c2891
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