Design and application of α-ketothioesters as 1,2-dicarbonyl-forming reagents

Conventionally, 1,2-dicarbonyl compounds are prepared via α-keto acyl chlorides. Here, the authors report a metal-free synthesis of α-ketothioester reagents via the combination of an α-hydroxyl ketone, elemental sulfur and a benzyl halide, which are used for N- or C-dicarbonyl bond formation.

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Autores principales:	Ming Wang, Zhihong Dai, Xuefeng Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/878544c6eb8c4e43a2d54ddad2779b72
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spelling	oai:doaj.org-article:878544c6eb8c4e43a2d54ddad2779b722021-12-02T15:35:09ZDesign and application of α-ketothioesters as 1,2-dicarbonyl-forming reagents10.1038/s41467-019-10651-w2041-1723https://doaj.org/article/878544c6eb8c4e43a2d54ddad2779b722019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10651-whttps://doaj.org/toc/2041-1723Conventionally, 1,2-dicarbonyl compounds are prepared via α-keto acyl chlorides. Here, the authors report a metal-free synthesis of α-ketothioester reagents via the combination of an α-hydroxyl ketone, elemental sulfur and a benzyl halide, which are used for N- or C-dicarbonyl bond formation.Ming WangZhihong DaiXuefeng JiangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ming Wang Zhihong Dai Xuefeng Jiang Design and application of α-ketothioesters as 1,2-dicarbonyl-forming reagents
description	Conventionally, 1,2-dicarbonyl compounds are prepared via α-keto acyl chlorides. Here, the authors report a metal-free synthesis of α-ketothioester reagents via the combination of an α-hydroxyl ketone, elemental sulfur and a benzyl halide, which are used for N- or C-dicarbonyl bond formation.
format	article
author	Ming Wang Zhihong Dai Xuefeng Jiang
author_facet	Ming Wang Zhihong Dai Xuefeng Jiang
author_sort	Ming Wang
title	Design and application of α-ketothioesters as 1,2-dicarbonyl-forming reagents
title_short	Design and application of α-ketothioesters as 1,2-dicarbonyl-forming reagents
title_full	Design and application of α-ketothioesters as 1,2-dicarbonyl-forming reagents
title_fullStr	Design and application of α-ketothioesters as 1,2-dicarbonyl-forming reagents
title_full_unstemmed	Design and application of α-ketothioesters as 1,2-dicarbonyl-forming reagents
title_sort	design and application of α-ketothioesters as 1,2-dicarbonyl-forming reagents
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/878544c6eb8c4e43a2d54ddad2779b72
work_keys_str_mv	AT mingwang designandapplicationofaketothioestersas12dicarbonylformingreagents AT zhihongdai designandapplicationofaketothioestersas12dicarbonylformingreagents AT xuefengjiang designandapplicationofaketothioestersas12dicarbonylformingreagents
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Design and application of α-ketothioesters as 1,2-dicarbonyl-forming reagents

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