Mining the Protein Data Bank to improve prediction of changes in protein-protein binding.

Predicting the effect of mutations on protein-protein interactions is important for relating structure to function, as well as for in silico affinity maturation. The effect of mutations on protein-protein binding energy (ΔΔG) can be predicted by a variety of atomic simulation methods involving full...

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Autores principales: Samuel Coulbourn Flores, Athanasios Alexiou, Anastasios Glaros
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
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Acceso en línea:https://doaj.org/article/8789d0a688944f57a85fb2a146ae0cb9
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