Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors

Alteration of the epigenetic landscape has been implicated in several disease processes, where targeting histone modifiers may have therapeutic applications. Here the authors report a bifunctional small molecule inhibitor that simultaneously targets the deacetylase (HDAC1) and demethylase (LSD1) act...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jay H. Kalin, Muzhou Wu, Andrea V. Gomez, Yun Song, Jayanta Das, Dawn Hayward, Nkosi Adejola, Mingxuan Wu, Izabela Panova, Hye Jin Chung, Edward Kim, Holly J. Roberts, Justin M. Roberts, Polina Prusevich, Jeliazko R. Jeliazkov, Shourya S. Roy Burman, Louise Fairall, Charles Milano, Abdulkerim Eroglu, Charlotte M. Proby, Albena T. Dinkova-Kostova, Wayne W. Hancock, Jeffrey J. Gray, James E. Bradner, Sergio Valente, Antonello Mai, Nicole M. Anders, Michelle A. Rudek, Yong Hu, Byungwoo Ryu, John W. R. Schwabe, Andrea Mattevi, Rhoda M. Alani, Philip A. Cole
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/879832a39de54eeeb00cc6a12113408e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:879832a39de54eeeb00cc6a12113408e
record_format	dspace
spelling	oai:doaj.org-article:879832a39de54eeeb00cc6a12113408e2021-12-02T16:49:17ZTargeting the CoREST complex with dual histone deacetylase and demethylase inhibitors10.1038/s41467-017-02242-42041-1723https://doaj.org/article/879832a39de54eeeb00cc6a12113408e2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02242-4https://doaj.org/toc/2041-1723Alteration of the epigenetic landscape has been implicated in several disease processes, where targeting histone modifiers may have therapeutic applications. Here the authors report a bifunctional small molecule inhibitor that simultaneously targets the deacetylase (HDAC1) and demethylase (LSD1) activities of the CoREST complex.Jay H. KalinMuzhou WuAndrea V. GomezYun SongJayanta DasDawn HaywardNkosi AdejolaMingxuan WuIzabela PanovaHye Jin ChungEdward KimHolly J. RobertsJustin M. RobertsPolina PrusevichJeliazko R. JeliazkovShourya S. Roy BurmanLouise FairallCharles MilanoAbdulkerim ErogluCharlotte M. ProbyAlbena T. Dinkova-KostovaWayne W. HancockJeffrey J. GrayJames E. BradnerSergio ValenteAntonello MaiNicole M. AndersMichelle A. RudekYong HuByungwoo RyuJohn W. R. SchwabeAndrea MatteviRhoda M. AlaniPhilip A. ColeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jay H. Kalin Muzhou Wu Andrea V. Gomez Yun Song Jayanta Das Dawn Hayward Nkosi Adejola Mingxuan Wu Izabela Panova Hye Jin Chung Edward Kim Holly J. Roberts Justin M. Roberts Polina Prusevich Jeliazko R. Jeliazkov Shourya S. Roy Burman Louise Fairall Charles Milano Abdulkerim Eroglu Charlotte M. Proby Albena T. Dinkova-Kostova Wayne W. Hancock Jeffrey J. Gray James E. Bradner Sergio Valente Antonello Mai Nicole M. Anders Michelle A. Rudek Yong Hu Byungwoo Ryu John W. R. Schwabe Andrea Mattevi Rhoda M. Alani Philip A. Cole Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors
description	Alteration of the epigenetic landscape has been implicated in several disease processes, where targeting histone modifiers may have therapeutic applications. Here the authors report a bifunctional small molecule inhibitor that simultaneously targets the deacetylase (HDAC1) and demethylase (LSD1) activities of the CoREST complex.
format	article
author	Jay H. Kalin Muzhou Wu Andrea V. Gomez Yun Song Jayanta Das Dawn Hayward Nkosi Adejola Mingxuan Wu Izabela Panova Hye Jin Chung Edward Kim Holly J. Roberts Justin M. Roberts Polina Prusevich Jeliazko R. Jeliazkov Shourya S. Roy Burman Louise Fairall Charles Milano Abdulkerim Eroglu Charlotte M. Proby Albena T. Dinkova-Kostova Wayne W. Hancock Jeffrey J. Gray James E. Bradner Sergio Valente Antonello Mai Nicole M. Anders Michelle A. Rudek Yong Hu Byungwoo Ryu John W. R. Schwabe Andrea Mattevi Rhoda M. Alani Philip A. Cole
author_facet	Jay H. Kalin Muzhou Wu Andrea V. Gomez Yun Song Jayanta Das Dawn Hayward Nkosi Adejola Mingxuan Wu Izabela Panova Hye Jin Chung Edward Kim Holly J. Roberts Justin M. Roberts Polina Prusevich Jeliazko R. Jeliazkov Shourya S. Roy Burman Louise Fairall Charles Milano Abdulkerim Eroglu Charlotte M. Proby Albena T. Dinkova-Kostova Wayne W. Hancock Jeffrey J. Gray James E. Bradner Sergio Valente Antonello Mai Nicole M. Anders Michelle A. Rudek Yong Hu Byungwoo Ryu John W. R. Schwabe Andrea Mattevi Rhoda M. Alani Philip A. Cole
author_sort	Jay H. Kalin
title	Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors
title_short	Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors
title_full	Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors
title_fullStr	Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors
title_full_unstemmed	Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors
title_sort	targeting the corest complex with dual histone deacetylase and demethylase inhibitors
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/879832a39de54eeeb00cc6a12113408e
work_keys_str_mv	AT jayhkalin targetingthecorestcomplexwithdualhistonedeacetylaseanddemethylaseinhibitors AT muzhouwu targetingthecorestcomplexwithdualhistonedeacetylaseanddemethylaseinhibitors AT andreavgomez targetingthecorestcomplexwithdualhistonedeacetylaseanddemethylaseinhibitors AT yunsong targetingthecorestcomplexwithdualhistonedeacetylaseanddemethylaseinhibitors AT jayantadas targetingthecorestcomplexwithdualhistonedeacetylaseanddemethylaseinhibitors AT dawnhayward targetingthecorestcomplexwithdualhistonedeacetylaseanddemethylaseinhibitors AT nkosiadejola targetingthecorestcomplexwithdualhistonedeacetylaseanddemethylaseinhibitors AT mingxuanwu targetingthecorestcomplexwithdualhistonedeacetylaseanddemethylaseinhibitors AT izabelapanova targetingthecorestcomplexwithdualhistonedeacetylaseanddemethylaseinhibitors AT hyejinchung targetingthecorestcomplexwithdualhistonedeacetylaseanddemethylaseinhibitors AT edwardkim targetingthecorestcomplexwithdualhistonedeacetylaseanddemethylaseinhibitors AT hollyjroberts targetingthecorestcomplexwithdualhistonedeacetylaseanddemethylaseinhibitors AT justinmroberts targetingthecorestcomplexwithdualhistonedeacetylaseanddemethylaseinhibitors AT polinaprusevich targetingthecorestcomplexwithdualhistonedeacetylaseanddemethylaseinhibitors AT jeliazkorjeliazkov targetingthecorestcomplexwithdualhistonedeacetylaseanddemethylaseinhibitors AT shouryasroyburman targetingthecorestcomplexwithdualhistonedeacetylaseanddemethylaseinhibitors AT louisefairall targetingthecorestcomplexwithdualhistonedeacetylaseanddemethylaseinhibitors AT charlesmilano targetingthecorestcomplexwithdualhistonedeacetylaseanddemethylaseinhibitors AT abdulkerimeroglu targetingthecorestcomplexwithdualhistonedeacetylaseanddemethylaseinhibitors AT charlottemproby targetingthecorestcomplexwithdualhistonedeacetylaseanddemethylaseinhibitors AT albenatdinkovakostova targetingthecorestcomplexwithdualhistonedeacetylaseanddemethylaseinhibitors AT waynewhancock targetingthecorestcomplexwithdualhistonedeacetylaseanddemethylaseinhibitors AT jeffreyjgray targetingthecorestcomplexwithdualhistonedeacetylaseanddemethylaseinhibitors AT jamesebradner targetingthecorestcomplexwithdualhistonedeacetylaseanddemethylaseinhibitors AT sergiovalente targetingthecorestcomplexwithdualhistonedeacetylaseanddemethylaseinhibitors AT antonellomai targetingthecorestcomplexwithdualhistonedeacetylaseanddemethylaseinhibitors AT nicolemanders targetingthecorestcomplexwithdualhistonedeacetylaseanddemethylaseinhibitors AT michellearudek targetingthecorestcomplexwithdualhistonedeacetylaseanddemethylaseinhibitors AT yonghu targetingthecorestcomplexwithdualhistonedeacetylaseanddemethylaseinhibitors AT byungwooryu targetingthecorestcomplexwithdualhistonedeacetylaseanddemethylaseinhibitors AT johnwrschwabe targetingthecorestcomplexwithdualhistonedeacetylaseanddemethylaseinhibitors AT andreamattevi targetingthecorestcomplexwithdualhistonedeacetylaseanddemethylaseinhibitors AT rhodamalani targetingthecorestcomplexwithdualhistonedeacetylaseanddemethylaseinhibitors AT philipacole targetingthecorestcomplexwithdualhistonedeacetylaseanddemethylaseinhibitors
_version_	1718383407279374336

Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors

Ejemplares similares